HIF-1[alpha]- and HIF-2[alpha]-Immunopositive Neurons and Capillaries in the Prefrontal Cerebral Cortex of Rats with Experimental Myocardial Infarction

• Published in: Bulletin of experimental biology and medicine Vol. 175; no. 1; p. 101
• Main Authors: Chertok, V.M, Nevzorova, V.A, Kotsyuba, A.E
• Format: Journal Article
• Language: English
• Published: Springer 01.05.2023
• Subjects: Brain; Heart attack; Neurons
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-023-05819-w

The quantitative content of HIF-1[alpha]- and HIF-2[alpha]-immunopositive brain neurons in Wistar rats was studied 1, 15, and 30 days after modeling of myocardial infarction. In rats of the control group, the immunohistochemical markers HIF-1[alpha] and HIF-2[alpha] in the prefrontal cortex of the brain were determined in few pale-colored neurons and capillaries. One day after myocardial infarction simulation, the number of [HIF-1[alpha].sup.+] neurons increased, and on day 15 it reached the maximum level: the concentration of immunopositive neurons and capillaries increased by 24.7 and 18.4%, respectively, in comparison with the control. After 30 days, the number of [HIF-1[alpha].sup.+] structures decreased, but remained above the control values. The number of neurons and capillaries positively stained for HIF-2[alpha] peaked only on day 30 of the postinfarction period. Key Words: brain; neurons and capillaries; HIF-1[alpha] and HIF-2[alpha]; myocardial infarction