Myocardial ischemic preconditioning upregulated protein 1(Mipu1):zinc finger protein 667--a multifunctional KRAB/[C.sub.2][H.sub.2] zinc finger protein

• Published in: Brazilian journal of medical and biological research Vol. 48; no. 1; p. 1
• Main Authors: Han, D, Zhang, C, Fan, W.J, Pan, W.J, Feng, D.M, Qu, S.L, Jiang, Z.S
• Format: Journal Article
• Language: English
• Published: Associacao Brasileira de Divulgacao Cientifica (ABDC) 01.01.2015
• Subjects: Gene expression; Genetic aspects; Myocardial ischemia; Zinc finger proteins
• ISSN: 0100-879X; 1414-431X
• DOI: 10.1590/1414-431X20144029

Myocardial ischemic preconditioning upregulated protein 1 (Mipu1) is a newly discovered upregulated gene produced in rats during the myocardial ischemic preconditioning process. M/pu1 cDNA contains a 1824-base pair open reading frame and encodes a 608 amino acid protein with an N-terminal Kruppel-associated box (KRAB) domain and classical zinc finger [C.sub.2][H.sub.2] motifs in the C-terminus. M/pu1 protein is located in the cell nucleus. Recent studies found that M/pu1 has a protective effect on the ischemia-reperfusion injury of heart, brain, and other organs. As a nuclear factor, M/pu1 may perform its protective function through directly transcribing and repressing the expression of proapoptotic genes to repress cell apoptosis. In addition, M/pu1 also plays an important role in regulating the gene expression of downstream inflammatory mediators by inhibiting the activation of activator protein-1 and serum response element. Key words: M/pu1; Zinc finger structure; Nuclear factor; Transcription and repression