Effects of repetitive transcranial magnetic stimulation on matrix metalloproteases levels and cognitive measures in MCI patients

To study the neurobiological effects of rTMS and its efficacy on cognitive functions, we selected a group of patients (n=27) affected by MCI that received daily/4 weeks high frequency (10 Hz) rTMS or sham stimulation, bilaterally, over the dorsolateral prefrontal cortex (DLPFC). Compared to the sham...

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Bibliographic Details
Published inItalian journal of anatomy and embryology Vol. 126; no. S1; pp. 173 - 174
Main Authors Cirillo, Giovanni, Pepe, Roberta, Esposito, Sabrina, Trojsi, Francesca, Papa, Michele
Format Journal Article
LanguageEnglish
Published Florence Firenze University Press 01.09.2022
Firenze University Press Università degli Studi di Firenze
Subjects
Alzheimer's disease
Analysis
Care and treatment
Cognitive ability
Interstitial collagenase
Magnetic fields
Matrix metalloproteinase
Nervous system diseases
Neurobiology
Neurophysiology
Patients
Prefrontal cortex
Transcranial magnetic stimulation
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Summary:To study the neurobiological effects of rTMS and its efficacy on cognitive functions, we selected a group of patients (n=27) affected by MCI that received daily/4 weeks high frequency (10 Hz) rTMS or sham stimulation, bilaterally, over the dorsolateral prefrontal cortex (DLPFC). Compared to the sham group, we report a significant reduction of MMP-1, 9 and 10 plasmatic levels paralleled by an increase of TIMPs at T2. [...]these data strongly correlate with the improvement of cognitive measures 6 months after rTMS. [...]we provide evidence of a long-term neurobiological effect of rTMS on MMPs system, that is paralleled by cognitive clinical improvement.
ISSN:1122-6714
2038-5129