Role of Dexmedetomidine Infusion on Renal Dysfunction in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Control Trial

ABSTRACT Objective: To find out the effect of Dexmedetomidine infusion on renal function in patients undergoing Coronary Artery Bypass Graft (CABG) surgery. Study Design: Randomized control trial (RCTNCT05375188). Place and Duration of Study: The research was conducted in the Department of Anesthesi...

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Bibliographic Details
Published inPakistan Armed Forces medical journal Vol. 72; p. S581
Main Authors Chohan, Haris Tariq, Khuwaja, Amin M, Ahmed, Sajjad, Ahmed, Aftab, Maaida Muzaffar, Siddiqui, Rashad
Format Journal Article
LanguageEnglish
Published Rawalpindi Knowledge Bylanes 31.10.2022
AsiaNet Pakistan (Pvt) Ltd
Subjects
Alzheimer's disease
Dexmedetomidine
Health aspects
Lead content
Nalbuphine
Neurodegeneration
Oxidative stress
Parkinson's disease
Sample size
Surgery
Systemic diseases
Trace elements
Pakistan
Karachi Pakistan
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Summary:ABSTRACT Objective: To find out the effect of Dexmedetomidine infusion on renal function in patients undergoing Coronary Artery Bypass Graft (CABG) surgery. Study Design: Randomized control trial (RCTNCT05375188). Place and Duration of Study: The research was conducted in the Department of Anesthesia, National Institute of Cardiovascular Diseases Karachi Pakistan, from Jun to Sep 2021. Methodology: 60 patients were allocated randomly into two groups. In GroupD, Dexmetedomidine was given as an infusion of 0.4 µg/kg/h from induction of anesthesia for 24 hours. In GroupC, patients were receiving an equal volume of normal saline. The primary outcome of the study was Serum Creatinine (mg/dl) which was measured 24 hours before the surgery as baseline and then 24 hours and 48 hours after surgery. Results: In GroupC Serum Creatinine was found to be 0.96 +/-0.21mg/dl at baseline, 1.02 +/-0.35 mg/dl after 24 hours and 1.38 +/-0.47 mg/dl after 48 hours of surgery. In GroupD Serum Creatinine was found to be 0.76 +/-0.12 mg/dl at baseline, 0.85 +/-0.17 mg/dl after 24 hours and 0.82+/-0.24 mg/dl after 48 hours of surgery. pvalue was found to be <0.001 after 48 hours of surgery. Conclusion: Dexmetedomidine infusion significantly reduced incidence of acute kidney injury in patients undergoing coronary artery bypass graft surgery.
ISSN:0030-9648
2411-8842