Association between the IFN-[gamma] and IL-1 genetic polymorphisms and colorectal cancer in the Chinese Han population

Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide (Sameer 2013). Over a 20 years period, the incidence of CRC has been increasing rapidly in China. CRC develops through a spec...

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Bibliographic Details
Published inJournal of genetics Vol. 93; no. 1; p. 235
Main Authors FEI, BAO-YING, LV, HUO-XIANG, CHENG, YONG-WEI, YANG, JIANG-MING
Format Journal Article
LanguageEnglish
Published London Springer 01.04.2014
Springer Nature B.V
Subjects
Colorectal cancer
Genetic aspects
Genetic polymorphisms
Medical laboratories
Polymorphism
Population genetics
China
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Summary:Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide (Sameer 2013). Over a 20 years period, the incidence of CRC has been increasing rapidly in China. CRC develops through a specic series of events, from the transformation of normal colonic epithelium to an adenomatous intermediate, and then ultimately adenocarcinoma (Pino and Chung 2010). Colitis-associated cancer (CAC) is the CRC subtype that is associated with inammatory bowel disease (IBD) (Rubin et al. 2012). The molecular mechanism of CRC is still not fully understood. Increased expression of proinammatory cytokines and inammatory inltration were found in colorectal cancer.
ISSN:0022-1333
0973-7731
DOI:10.1007/s12041-014-0354-3