Definition of two angiogenic pathways by distinct alphav integrins

Two cytokine-dependent pathways of angiogenesis were shown to exist and were defined by their dependency on distinct vascular cell integrins. In vivo angiogenesis in corneal or chorioallantoic membrane models induced by basic fibroblast growth factor or by tumor necrosis factor-alpha depended on alp...

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Published inScience (American Association for the Advancement of Science) Vol. 270; no. 5241; p. 1500
Main Authors Friedlander, Martin, Brooks, Peter C, Shaffer, Robert W, Kincaid, Christine M
Format Journal Article
LanguageEnglish
Published Washington The American Association for the Advancement of Science 01.12.1995
Subjects
Blood vessels
Eyes & eyesight
Individualized Instruction
Poultry
Rabbits
Redundancy
Tumors
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Summary:Two cytokine-dependent pathways of angiogenesis were shown to exist and were defined by their dependency on distinct vascular cell integrins. In vivo angiogenesis in corneal or chorioallantoic membrane models induced by basic fibroblast growth factor or by tumor necrosis factor-alpha depended on alphavbeta3, whereas angiogenesis inititated by vascular endothelial growth factor, transforming growth factor-alpha, or phorbol ester depended on alphavbeta5.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0036-8075
1095-9203