PI3K/AKT/mTOR Signaling Network in Human Health and Diseases

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2025
• Subjects: AGC kinases; AKT; AKT1; amino acid signaling; AMPK; apoptosis; ascorbic acid; astrocytes; autophagic flux blockage; autophagy; Biology, life sciences; bone marrow mesenchymal stem cells; bone microvascular endothelial cells; breast cancer; BX795; cancer; cancer therapeutics; CCT/TRiC; CCTβ; cell penetrating peptide; cellular signaling; chaperonin; colorectal cancer; combination therapy; corneal endothelial cells; cytokines; diabetes; dihydroartemisinin; DNA damage; EGFR pathway; emerging functions and targets; epilepsy; epithelial–mesenchymal transition; extracellular vesicles; ferroptosis; fibrosis; focal adhesion kinase; galectin-1; GATOR complex; GSI; HCC; heart failure; hepatocellular cancer; inflammation; JC polyomavirus; kinase; left ventricular remodeling; LIHC; lysosome; mammalian target of rapamycin; MAPK/ERK; Mathematics and Science; metabolism; mTOR; mTORC1; mTORC1 pathway; mTORC2; muscle protein synthesis; myocardial infarction; n/a; necroptosis; neurological disorders; nutrients; oxidative stress; p90 ribosomal s6 kinase; PDK1; phosphoinositide 3-kinases; phosphoinositide-dependent kinase (PDK1); Physics; PI3K; PI3K/Akt; PI3K/Akt pathway; PI3K/AKT/mTOR pathway; PIK3CA; PML; primary cells; protein kinase B (AKT1); psoriasis; PTEN; pyroptosis; radioresistance; radiotherapy; rapamycin; raptor; recombinant protein; Reference, Information and Interdisciplinary subjects; Research and information: general; resveratrol; rhabdomyosarcoma; RNA-sequencing; RSK; SEA complex; selective inhibitor; starvation; stemness; survival; SVGA cells; TFEB agonists; Thermodynamics and heat; trans-activator of transcription (TAT); transcriptome; tuberous sclerosis complex; tumor heterogeneity; upper urinary urothelial carcinoma; wortmannin
• ISBN: 9783725827732; 3725827737; 9783725827749; 3725827745
• DOI: 10.3390/books978-3-7258-2773-2

In recent years, researchers have shown a special interest in the role of signaling pathways as disease molecular targets and capitalized on such pathways to derive natural products, biologics, and synthetic scaffold-based prevention and treatments. These can lead to naturally available, efficacious, low-cost, and minimally toxic long-term therapies for human diseases. This Special Issue of Cells comprises an array of literature reviews, original communications, and studies on the roles of the PI3K/AKT/mTOR and associated pathways in a diversity of pathways using in vitro cell-based assays and preclinical animal models. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of human disorders, the wealth of information published in this Special Issue can act as a springboard for the identification of novel disease targets and the development of new preventive and therapeutic modalities for the management of human diseases.