Fabrication and characterization of Zr[O.sub.2]-CaO-[P.sub.2][O.sub.5]-[Na.sub.2]O-Si[O.sub.2] bioactive glass ceramics

• Published in: Journal of materials science Vol. 48; no. 5; pp. 1863 - 1872
• Main Authors: Mondal, Dibakar, So-Ra, Son, Lee, Byong Taek
• Format: Journal Article
• Language: English
• Published: Springer 01.03.2013
• Subjects: Analysis; Ceramic materials; Ceramics; Chemical properties; Diffraction; Lime; Mechanical properties; X-rays
• ISSN: 0022-2461; 1573-4803
• DOI: 10.1007/s10853-012-6956-3

Si[O.sub.2]-CaO-[Na.sub.2]O-[P.sub.2][O.sub.5]-Zr[O.sub.2] based bioactive glasses with different compositions of Si[O.sub.2] and yttrium stabilized Zr[O.sub.2] were prepared by the conventional melt quenching technique. The effects on the chemical-mechanical properties of bioactive glasses due to the addition of Zr[O.sub.2] by replacing Si[O.sub.2] were investigated. Microstructure and phase behavior were studied by scanning electron microscopy, energy-dispersive spectroscopy, and X-ray diffraction analysis. Compressive strength, porosity, Vickers hardness, and Young's modulus were measured as mechanical properties. Bioactivity and cell viability were investigated by immersion in simulated body fluid and MTT assay analysis. Osteosarcoma cell proliferation on the specimen surfaces was examined by confocal laser scanning microscopy. The results showed that replacing Si[O.sub.2] with Zr[O.sub.2] helps the bioactive glass to be completely vitrified at comparatively lower sintering temperature than conventional Bioglass®. The mechanical properties were also improved without compromising biocompatibility. Bioactive glass containing 10 wt% Zr[O.sub.2] and 35 wt% Si[O.sub.2] showed compressive strength of 399.71 MPa, Young's modulus of 22.3 GPa, Vicker's hardness of 502.54 HV, and porosity of 26 vol%.