Assessment of cases with thrombosis in the neonatal period and results of one-year-follow-up/ Yenidogan doneminde tromboz saptanan olgularin degerlendirilmesi ve bir yillik izlem sonuclari

• Published in: Turk Pediatri Arsivi p. 120
• Main Authors: Bulbul, Lida Gunes, Can, Emrah, Nuhoglu, Asiye, Bulbul, Ali
• Format: Journal Article
• Language: Turkish
• Published: AVES 01.12.2009
• Subjects: Blood clot; Care and treatment; Diagnosis; Diseases; Infants; Infants (Newborn); Medical examination; Patient outcomes; Prognosis; Risk factors; Thrombosis; Turkey
• ISSN: 1306-0015

Aim: We aimed to investigate thrombotic cases determined in the neonatal period for one year and to assess their prognosis in one-year follow-up. Material and Method: All thrombotic neonatal patients in the year 2007 were involved in the study. Prospectively recorded data included sex, gestational age, week of the first determined symptoms, perinatal risk factors, radiological findings, localization of thrombosis, type and duration of applied treatment, blood count and coagulation tests at diagnosis, prothrombotic state tests, follow-up results in the neonatal period and in the following year. Results: Five patients, all males, developed thrombosis in the mentioned period. Mean gestational age, birth weight and postnatal age when the thrombosis was diagnosed were 34 weeks; 2,352 g and 11 days respectively. Risk factors were preterm birth (two patients), difficult vaginal delivery, preeclampsia, gestational diabetes and dehydratation. Localization sites of thrombosis were inferior caval vein, left portal vein, left saphena magna vein, left sinus venosus, and right renal vein. Further investigations revealed antithrombin-3 deficiency in a patient. In the one-year follow-up period, a patient died due to sudden infant death and neurodevelopmental delay was found in another patient. Conclusions: Early diagnosis and treatment of thrombosis in the neonatal period reduces mortality and morbidity rates. Thus, there is a need for awareness of risk factors in the development of thrombosis, and precantions must be taken in those patients against the development of thrombosis. (Turk Arch Ped 2009; 44: 120-3) Key words: Morbidity, newborn, prognosis, risk factors, thrombosis, thrombophilia Amac: Calismamizda yenidogan doneminde bir yillik surede saptanan tromboz olgularinin incelenmesi ve bu bebeklerin bir yillik izlem lerinde seyirlerinin degerlendirilmesi amaclandi. Gerec ve Yontem: Bir yillik sure icerisinde (2007 yili) yenidogan doneminde tromboz saptanan tum hastalar calismaya alindi. Ileriye donuk olarak hastalarin; cinsiyet, gebelik haftasi, ilk bulgularin saptandigi yas, perinatal risk etmenleri, radyografik bulgular, trombozun saptandigi alan, uygulanan tedavi sekli ve suresi, tromboz saptandiginda bakilan kan sayimi ve pihtilasma testleri, protrombotik durum testleri, yenidogan donemi ve bir yasindaki izlem sonuclari kaydedildi. Bulgular: Belirlenen surede bes hastada tromboz gelistigi saptandi. Hastalarin besi de erkekti. Ortalama gebelik haftasi, dogum agirligi ve trombozun saptandigi dogum sonrasi yas sirasiyla 34 hafta, 2352 gr ve 11 gun idi. Saptanan risk etkenleri erken dogum (iki hasta), zor dogum, preeklampsi, gebelik diyabeti ve dehidratasyon idi. Trombozun saptandigi alanlar v. cava inferior, sol portal ven, sol v. saphena magna, sol sinus venosus ve sag renal ven idi. Ileri incelemelerde bir olguda antitrombin III eksikligi belirlendi. Bir yillik izlemde bir bebek ani bebek olumu nedeniyle kaybedildi. Diger bir bebegin ise noromotor gelisiminin geri oldugu saptandi. Cikarimlar: Yenidogan doneminde trombozun erken tani ve tedavisi erken donem hastalik ve olum oranini azaltir. Bu nedenle tromboz gelisiminde risk etkenleri iyi bilinmeli ve bu risk etkenlerine sahip hastalarda tromboz gelisme olasiligina karsi dikkatli olunmali ve gerekli onlemler alinmalidir. (Turk Ped Ars 2009; 44: 120-3) Anahtar kelimeler: Erken donem hastalik orani, risk etkenleri, seyir, trombofili, tromboz, yenidogan