Molecular analysis of hepatitis B virus

Occult hepatitis B virus (HBV) infection (OBI) is characterized by HBV DNA persistence even though the pattern of serological markers indicates an otherwise resolved HBV infection. Although OBI is usually clinically silent, immunocompromised patients may experience reactivation of the liver disease....

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Published inBMC infectious diseases Vol. 11; pp. 310 - 619
Main Authors Costantini, Andrea, Marinelli, Katia, Biagioni, Giulia, Monachetti, Alessia, Ferreri, Monica L, Butini, Luca, Montroni, Maria, Manzin, Aldo, Bagnarelli, Patrizia
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 04.11.2011
Subjects
Drug therapy
Hepatitis B
HIV infection
Patient outcomes
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Summary:Occult hepatitis B virus (HBV) infection (OBI) is characterized by HBV DNA persistence even though the pattern of serological markers indicates an otherwise resolved HBV infection. Although OBI is usually clinically silent, immunocompromised patients may experience reactivation of the liver disease. This case stresses the ability of HBV to evolve continuously, even during occult infection, and the effectiveness of ART in controlling OBI reactivation in HIV-infected individuals.
ISSN:1471-2334
1471-2334
DOI:10.1186/1471-2334-11-310