Biallelic Loss of 7q34 in Adult Ph-Negative Acute T-Lymphoblastic Leukemia

Tumor cells of acute lymphoblastic leukemia (ALL) may have various genetic abnormalities. Some of them lead to a complete loss of certain genes. Our aim was to reveal biallelic deletions of genes in Ph–negative T-ALL. Chromosomal microarray analysis (CMA) was performed for 47 patients with de novo P...

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Published inInternational journal of molecular sciences Vol. 25; no. 19
Main Authors Risinskaya, Natalya, Abdulpatakhov, Abdulpatakh, Chabaeva, Yulia, Aleshina, Olga, Gladysheva, Maria, Nikulina, Elena, Bolshakov, Ivan, Yushkova, Anna, Dubova, Olga, Vasileva, Anastasia, Obukhova, Tatiana, Julhakyan, Hunan, Kapranov, Nikolay, Galtseva, Irina, Kulikov, Sergey, Sudarikov, Andrey, Parovichnikova, Elena
Format Journal Article
LanguageEnglish
Published MDPI AG 01.10.2024
Subjects
Acute lymphocytic leukemia
Cancer
Chromosome deletion
Development and progression
Genetic aspects
Oncology, Experimental
Prognosis
Russia
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Summary:Tumor cells of acute lymphoblastic leukemia (ALL) may have various genetic abnormalities. Some of them lead to a complete loss of certain genes. Our aim was to reveal biallelic deletions of genes in Ph–negative T-ALL. Chromosomal microarray analysis (CMA) was performed for 47 patients with de novo Ph–negative T-ALL, who received treatment according to RALL-2016m clinical protocol at the National Medical Research Center for Hematology (Moscow, Russia) from 2017 to 2023. Out of forty-seven patients, only three had normal molecular karyotype. The other 44 patients had multiple gains, losses, and copy neutral losses of heterozygosity. Biallelic losses were found in 14 patients (30%). In ten patients (21%), a biallelic deletion of 9p21.3 involved a different number of genes, however CDKN2A gene loss was noted in all ten cases. For seven patients (15%), a biallelic deletion of 7q34 was found, including two genes—PRSS1 , PRSS2 located within the T-cell receptor beta (TRB ) locus. A clonal rearrangement of the TRB gene was revealed in 6 out of 7 cases with 7q34 biallelic loss. Both biallelic deletions can be considered favorable prognostic factors, with an association with 9p21 being statistically significant (p = 0.01) and a trend for 7q34 (p = 0.12) being observed.
ISSN:1422-0067
DOI:10.3390/ijms251910482