Association of NOS3 gene polymorphisms with increased risk of ESRD among Egyptian patients

• Published in: Journal of Genetic Engineering and Biotechnology Vol. 19; no. 1
• Main Authors: Elsaid, Afaf, Samir eid, Omnia, Said, Samy B, Zahran, Rasha F
• Format: Journal Article
• Language: English
• Published: Springer 18.10.2021
• Subjects: Chronic kidney failure; Comparative analysis; Development and progression; Egypt; Ethylenediaminetetraacetic acid; Genes; Genetic aspects; Genetic polymorphisms; Genetic research; Mortality; Egypt
• ISSN: 1687-157X
• DOI: 10.1186/s43141-021-00260-w

Background Chronic kidney Failure (CKD), particularly End-Stage Renal Disease (ESRD), may be serious ill-health related to a high death rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Our study aimed at identifying the association of NOS3 (rs 2070744) and SOD2 Val16Ala (rs4880) gene polymorphisms within ESRD Egyptian patients. Methods This work was conducted on 100 ESRD and 16 CKD Egyptian patients who were compared to 100 healthy controls. DNA was genotyped for these variants using the (T-ARMS-PCR) technique. Results ESRD patients showed a significant association of the genotype of NOS3 gene polymorphism compared with healthy controls (P = 0.032). In the contrast, the present study revealed that no statistically significant differences were found among the CKD, ESRD, and control groups as regards the SOD2 genotypes (P = 0.064). Conclusions Our findings indicated a significant association between NOS3 (rs 2070744) gene polymorphism and increased risk of ESRD and CKD among Egyptian patients.