Association of NOS3 gene polymorphisms with increased risk of ESRD among Egyptian patients

Background Chronic kidney Failure (CKD), particularly End-Stage Renal Disease (ESRD), may be serious ill-health related to a high death rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Our study aimed at identifying the association of NOS3 (rs 2070744) and S...

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Bibliographic Details
Published inJournal of Genetic Engineering and Biotechnology Vol. 19; no. 1
Main Authors Elsaid, Afaf, Samir eid, Omnia, Said, Samy B, Zahran, Rasha F
Format Journal Article
LanguageEnglish
Published Springer 18.10.2021
Subjects
Chronic kidney failure
Comparative analysis
Development and progression
Egypt
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic polymorphisms
Genetic research
Mortality
Egypt
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ISSN1687-157X
DOI10.1186/s43141-021-00260-w

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Summary:Background Chronic kidney Failure (CKD), particularly End-Stage Renal Disease (ESRD), may be serious ill-health related to a high death rate. Uremic syndrome leads to increased oxidative stress, inflammation, and dyslipidemia. Our study aimed at identifying the association of NOS3 (rs 2070744) and SOD2 Val16Ala (rs4880) gene polymorphisms within ESRD Egyptian patients. Methods This work was conducted on 100 ESRD and 16 CKD Egyptian patients who were compared to 100 healthy controls. DNA was genotyped for these variants using the (T-ARMS-PCR) technique. Results ESRD patients showed a significant association of the genotype of NOS3 gene polymorphism compared with healthy controls (P = 0.032). In the contrast, the present study revealed that no statistically significant differences were found among the CKD, ESRD, and control groups as regards the SOD2 genotypes (P = 0.064). Conclusions Our findings indicated a significant association between NOS3 (rs 2070744) gene polymorphism and increased risk of ESRD and CKD among Egyptian patients.
ISSN:1687-157X
DOI:10.1186/s43141-021-00260-w