F- and [sup.11]C-labelling of quantum dots with n.c.a. [[sup.18]F]fluoroethyltosylate and [[sup.11]C]methyliodide: a feasibility study

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 283; no. 2; p. 487
• Main Authors: Patt, M, Schildan, A, Habermann, B, Mishchenko, O, Patt, J.T, Sabri, O
• Format: Journal Article
• Language: English
• Published: Springer 01.02.2010
• Subjects: Chromatography; Fluorescence; PET imaging
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-009-0356-4

Quantum dots functionalized on the outer surface with either amino- or carboxyl functions were labelled with [[sup.18]F]fluoroethyltosylate and [[sup.11]C]methyliodide in order to use the positron emitter-labelled fluorescence agents for multimodality imaging techniques, i.e. fluorescence imaging and positron emission tomography. [sup.18]F-Labelling of both compounds was realized with yields up to 5% as determined by size exclusion chromatography, which is twice as much as reported in literature before [1]. [sup.11]C-Labelling of amino- and carboxyl-QDs proceeded with good yields (up to 45 and 35%, respectively) under optimized reaction conditions. In general for both QD-types and both labelling agents the labelling yield increased with the amount of QDs used in the reaction as well as with reaction time and reaction temperature. Keywords Quantum dot * PET * [sup.18]F * [sup.11]C * Size exclusion chromatography