The Intricate Relationship between Type 2 Diabetes Mellitus

Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa....

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Bibliographic Details
Published inJournal of Diabetes Research Vol. 2020
Main Authors Tanase, Daniela Maria, Gosav, Evelina Maria, Costea, Claudia Florida, Ciocoiu, Manuela, Lacatusu, Cristina Mihaela, Maranduca, Minela Aida, Ouatu, Anca, Floria, Mariana
Format Journal Article
LanguageEnglish
Published Hindawi Limited 31.08.2020
Subjects
Amino acids
Chronic diseases
Epidemiology
Fatty liver
Health aspects
Hypoglycemic agents
Insulin resistance
Medical research
Prevalence studies (Epidemiology)
Type 2 diabetes
Romania
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Summary:Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
ISSN:2314-6745
DOI:10.1155/2020/3920196