The Prognostic and Diagnostic Value of [[sup.18]F]FDG PET/CT in Untreated Laryngeal Carcinoma

• Published in: Journal of clinical medicine Vol. 12; no. 10
• Main Authors: Al-Ibraheem, Akram, Abdlkadir, Ahmed Saad, Al-Adhami, Dhuha, Hejleh, Taher Abu, Mansour, Asem, Mohamad, Issa, Juweid, Malik E, Al-Rasheed, Ula, Al-Hajaj, Nabeela, Laban, Dima Abu, Estrada-Lobato, Enrique, Saraireh, Omar
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.05.2023
• Subjects: CT imaging; Diagnosis; Laryngeal cancer; PET imaging; Prognosis; Jordan
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12103514

This study aims to determine the diagnostic accuracy of staging PET/CT and neck MRI in patients with laryngeal carcinoma and to assess the value of PET/CT in predicting progression-free survival (PFS) and overall survival (OS). Sixty-eight patients who had both modalities performed before treatment between 2014 and 2021 were included in this study. The sensitivity and specificity of PET/CT and MRI were evaluated. PET/CT had 93.8% sensitivity, 58.3% specificity, and 75% accuracy for nodal metastasis, whereas MRI had 68.8%, 61.1%, and 64.7% accuracy, respectively. At a median follow-up of 51 months, 23 patients had developed disease progression and 17 patients had died. Univariate-survival analysis revealed all utilized PET parameters as significant prognostic factors for OS and PFS (p-value < 0.03 each). In multivariate analysis, metabolic-tumor volume (MTV) and total lesion glycolysis (TLG) predicted better PFS (p-value < 0.05 each). In conclusion, PET/CT improves the accuracy of nodal staging in laryngeal carcinoma over neck MRI and adds to the prognostication of survival outcomes through the use of several PET metrics.