PANETH CELL-LIKE COMPONENT IN PROSTATE CANCER - CASE REPORT/KARCINOM PROSTATE S KOMPONENTOM NALIK NA PANETHOVE STANICE - PRIKAZ SLUCAJA

Prostate adenocarcinoma with Paneth cell-like neuroendocrine differentiation is a rare entity. Foci of scattered cells and small clusters are found in the majority of described cases, although cases with predominant Paneth cell-like features have also been recorded. These cells contain eosinophilic...

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Published inActa clinica Croatica (Tisak) Vol. 57; no. S1; p. 85
Main Authors Sojat, Josip, Juric, Bernardica, Soipi, Soip, Ulamec, Monika, Kruslin, Bozo
Format Journal Article
LanguageEnglish
Published Klinicki bolnicki centar Sestre milosrdnice 15.03.2018
Subjects
Analysis
Care and treatment
Case studies
Diagnosis
Health aspects
Measurement
Prostate cancer
Prostate specific antigen
Croatia
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Summary:Prostate adenocarcinoma with Paneth cell-like neuroendocrine differentiation is a rare entity. Foci of scattered cells and small clusters are found in the majority of described cases, although cases with predominant Paneth cell-like features have also been recorded. These cells contain eosinophilic cytoplasmic inclusions and lack androgen receptors, and are consequently immune to hormone therapy. It is, therefore, important for pathologists to recognize them. According to literature, clinical outcome depends on the standard grading of the conventional prostate cancer component. We report a case of a 54 year-old patient with prostatic adenocarcinoma showing Paneth celllike neuroendocrine differentiation.Key words: Prostate; Adenocarcinoma; Paneth cellsAdenokarcinom prostate s neuroendokrinom diferencijacijom u obliku komponente koja nalikuje Panethovim stanicama je vrlo rijedak entitet. Rasprsene neuroendokrine stanice nalik Panethovima mogu se naci u vecini opisanih slucajeva, iako se nalaze i primjeri s predominantnom komponentom navedenih stanica. One sadrze eozinofilne citoplazmatske inkluzije, a nedostaju im androgeni receptori te su stoga imuni na hormonsku terapiju, a sto je jedan od glavnih razloga da ih patolozi prepoznaju. Prema dostupnoj literaturi, klinicki ishod takvih tumora ovisi o standardnim parametrima, ponajprije o gradusu konvencionalne komponente karcinoma prostate. Ovdje opisujemo 54-godisnjeg bolesnika s adenokarcinomom prostate koji pokazuje neuroendokrinu diferencijaciju tipa stanica nalik Panethovim.Kljucne rijeci: Prostata; Adenokarcinom; Panethove stanice
ISSN:0353-9466
1333-9451
DOI:10.20471/acc.2018.57.s1.13