Association of Serum 25D Deficiency with High Viral Load in HBV Infected Patients

Hepatitis B virus (HBV) is a significant public health concern, particularly in low-income countries. The host immune response plays an essential role in hepatitis B virus outcome, mainly orchestrated by cytokines and immune modulators molecules such as vitamin D. This study aimed to determine the l...

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Published inJournal of pure & applied microbiology : an international research journal of microbiology Vol. 16; no. 3; p. 1643
Main Authors Amien, Nada Mohamed Hassan, Alameen, Ayman Ali Mohammed, Junaid, Kashaf, Abdalla, Abualgasim Elgaili, Awadelkarim, Mona O.A, Siddig, Hind M, Bilal, Naser Eldin
Format Journal Article
LanguageEnglish
Published Oriental Scientific Publishing Company 01.09.2022
Subjects
Alfacalcidol
Biological response modifiers
Calcifediol
Enzymes
Health aspects
Hepatitis B
Hepatitis C virus
Immune response
Interferon
Liver
Liver diseases
Vitamin D
Sudan
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Summary:Hepatitis B virus (HBV) is a significant public health concern, particularly in low-income countries. The host immune response plays an essential role in hepatitis B virus outcome, mainly orchestrated by cytokines and immune modulators molecules such as vitamin D. This study aimed to determine the levels of cytokines (IL-10), interferon-gamma (IFN-gamma), interferon-lambada (IFN-lambada), granzyme B, and vitamin D in Khartoum, Sudan, and to assess the association between them and variable HBV viral load as well as liver enzyme levels. A total of 174 participants were enrolled in the trial, with 100 HBV-infected patients (who were HIV and HCV negative) and 74 healthy volunteers. Patients' HBV viral load, vitamin D levels, liver enzymes, and circulatory cytokines were measured. This study revealed a remarkable decrease in vitamin D levels in HBV infected patients with an elevation in levels of liver biomarkers. The level of IL-10 was significantly higher in patients than in apparently healthy controls (p-value <0.001). There was a positive correlation between IFN-[gamma], Granzyme B, and viral load. According to the findings of this study, there is a marked hypovitaminosis D among hepatitis B infected patients with a significant increase in IL-10, which may implicate the persistence of HBV infection. Moreover, HBV DNA levels were significantly associated with IFN- [gamma] and granzyme B levels. Keywords: Hepatitis B Virus, Cytokines, Vitamin D
ISSN:0973-7510
DOI:10.22207/JPAM.16.3.02