Bioactivities of Steroids and Sesquiterpenes from the Branches and Leaves of IAglaia lawii/I

Five undescribed steroids and one sesquiterpene, named Aglaians A–F, along with sixteen known analogs, have been isolated from the branches and leaves of Aglaia lawii. Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calcu...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 1
Main Authors Dong, Jingjing, Liu, Hanfei, Wang, Huan, Lou, Huayong, Pan, Weidong, Li, Jinyu
Format Journal Article
LanguageEnglish
Published MDPI AG 01.12.2023
Subjects
Medicine, Botanic
Medicine, Herbal
Sesquiterpenes
China
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Summary:Five undescribed steroids and one sesquiterpene, named Aglaians A–F, along with sixteen known analogs, have been isolated from the branches and leaves of Aglaia lawii. Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The cytotoxic and antibacterial activities of six human tumor cell lines were evaluated (MDA-MB-231, MCF-7, Ln-cap, A549, HeLa, and HepG-2), and four strains of bacteria (Bacterium subtilis, Phytophthora cinnamomic, Acrogenic bacterium, and Ralstonia solanacearum). The bioassay results indicated that compounds 3 and 5 exhibited moderate antitumor activity with IC[sub.50] values ranging from 16.72 to 36.14 μM. Furthermore, compounds 3–5 possess antibacterial activities against four bacteria with MIC values of 25–100 μM.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29010039