Bioactivities of Steroids and Sesquiterpenes from the Branches and Leaves of IAglaia lawii/I
Five undescribed steroids and one sesquiterpene, named Aglaians A–F, along with sixteen known analogs, have been isolated from the branches and leaves of Aglaia lawii. Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calcu...
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Published in | Molecules (Basel, Switzerland) Vol. 29; no. 1 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
MDPI AG
01.12.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Five undescribed steroids and one sesquiterpene, named Aglaians A–F, along with sixteen known analogs, have been isolated from the branches and leaves of Aglaia lawii. Its structure was elucidated by IR, HRESIMS, 1D and 2D NMR, quantum-chemical calculations, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The cytotoxic and antibacterial activities of six human tumor cell lines were evaluated (MDA-MB-231, MCF-7, Ln-cap, A549, HeLa, and HepG-2), and four strains of bacteria (Bacterium subtilis, Phytophthora cinnamomic, Acrogenic bacterium, and Ralstonia solanacearum). The bioassay results indicated that compounds 3 and 5 exhibited moderate antitumor activity with IC[sub.50] values ranging from 16.72 to 36.14 μM. Furthermore, compounds 3–5 possess antibacterial activities against four bacteria with MIC values of 25–100 μM. |
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ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules29010039 |