Evaluation of Diffusion Tensor Imaging Findings in Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis Patients/Klinik Izole Sendrom ve Relapsing-Remmitting Multipl Skleroz Hastalarinda Difuzyon Tensor Goruntuleme Bulgularinin Degerlendirilmesi

• Published in: Türk nöroloji dergisi Vol. 29; no. 1; p. 40
• Main Authors: Alatas, Ozkan, Cavusoglu, Berrin, Caylak, Ali, Keskin, Onur, Idiman, Egemen, Idiman, Fethi, Ada, Emel
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.03.2023
• Subjects: Corpus callosum; Diagnosis; Magnetic resonance imaging; Medical examination; Multiple sclerosis; Neuroimaging; Turkey
• ISSN: 1301-062X; 1309-2545
• DOI: 10.4274/tnd.2022.17363

Objective: To compare diffusion tensor imaging (DTI) findings of the normal-appearing white matter (NAWM) and corpus callosum (CC) in patients with clinically isolated syndrome (CIS) and relapsing-remitting multiple sclerosis (RRMS) and a healthy control (HC) group. Materials and Methods: The CIS (n = 10), RRMS (n = 29), and HC (n = 13) groups were evaluated by DTI in this retrospective study. Mean diffusion (MD) and fractional anisotropy (FA) maps as well as MD and FA measurements were made from the corpus callosum genu (CCG), corpus callosum splenium (CCS), and NAWM areas from the frontal, parietal, occipital and temporal lobes. Results: The mean FA values of the NAWM in the temporal lobes were bilaterally lower in both the CIS and RRMS groups than in the HC group. However, no difference was found between the CIS and RRMS groups. In addition, the CIS group had lower FA values in the CCG, whereas the RRMS group had lower FA values in the CCS compared with the HC group. The MD values were significantly different in the CCG between the RRMS and HC groups. Conclusion: DTI contributes to detecting early changes in the NAWM and CC in patients diagnosed with CIS and RRMS. Additionally, DTI can aid in the follow-up care and management of these patients. Keywords: Clinically isolated syndrome, relapse-remitting multiple sclerosis, diffusion tensor imaging Amac: Klinik izole sendrom (KIS) ve relapsing-remmiting multipl skleroz (RRMS) tanisi almis olan hastalar ile saglikli kontrollerde normal gorunen beyaz cevher (NGBC) ve korpus kallozumda difuzyon tensor goruntuleme (DTG) bulgularini arastirmaktir. Gerec ve Yontem: Retrospektif calismada KIS (n = 10), RRMS (n = 29) ve saglikli kontrol (n = 13) gruplari DTG ile degerlendirildi.Ortalama difuzyon (OD) ve fraksiyonel anizotropi (FA) haritalarinda korpus kallozum genu (KKG) ve spleniumdan (KKS), frontal, parietal, occipital ve temporal loblar NGBC alanlarindan OD ve FA olcumleri yapildi. Bulgular: Temporal loblardaki NBGC'nin ortalama FA degerleri hem KIS hem de RRMS'de bilateral olarak kontrol grubundan daha dusuktu. Ancak, KIS ve RRMS gruplari arasinda fark bulunmadi. KIS grubu KKG'de kontrol grubuna gore daha dusuk FA degerlerine sahipken, RRMS grubu KKS'de kontrollere kiyasla daha dusuk FA degerlerine sahipti. RRMS ve kontroller arasinda KKG'de OD degerleri istatistiksel olarak farkliydi. Sonuc: DTG, KIS ve RRMS hastalarinda NGBC ve korpus kallozumdaki erken degisikliklerin saptanmasina katkida bulunur. DTG, KIS ve RRMS hastalarinin takibi ve yonetimine yardimci olabilir. Anahtar Kelimeler: Klinik izole sendrom, relapsing-remmitting multipl skleroz, difuzyon tensor goruntuleme