Substituted [beta]-mercapto ketone based synthesis of 3-alkyl-3-[methyl]-2-methyl-3H-indoles

A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1H-indoles was developed based on the Fischer indole synthesis involving accessible [beta]-mercapto ketones. Heterocyclization of 3-[(alkylsulfanyl)methyl]alkan-2-ones and phenylhydrazine by the action of ZnCl.sub.2 in MeOH or...

Full description

Saved in:
Bibliographic Details
Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 57; no. 5; p. 543
Main Authors Baeva, Larisa Ð, Nugumanov, Radik M, Gataullin, Rail R, Fatykhov, Akhnef Ð
Format Journal Article
LanguageEnglish
Published Springer 01.05.2021
Subjects
Antiviral agents
Hydrazine
Nitriles
Online AccessGet full text

Cover

More Information
Summary:A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1H-indoles was developed based on the Fischer indole synthesis involving accessible [beta]-mercapto ketones. Heterocyclization of 3-[(alkylsulfanyl)methyl]alkan-2-ones and phenylhydrazine by the action of ZnCl.sub.2 in MeOH or EtOH gave previously unknown 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-021-02940-4