Substituted [beta]-mercapto ketone based synthesis of 3-alkyl-3-[methyl]-2-methyl-3H-indoles
A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1H-indoles was developed based on the Fischer indole synthesis involving accessible [beta]-mercapto ketones. Heterocyclization of 3-[(alkylsulfanyl)methyl]alkan-2-ones and phenylhydrazine by the action of ZnCl.sub.2 in MeOH or...
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Published in | Chemistry of heterocyclic compounds (New York, N.Y. 1965) Vol. 57; no. 5; p. 543 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Springer
01.05.2021
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Subjects | |
Online Access | Get full text |
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Summary: | A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1H-indoles was developed based on the Fischer indole synthesis involving accessible [beta]-mercapto ketones. Heterocyclization of 3-[(alkylsulfanyl)methyl]alkan-2-ones and phenylhydrazine by the action of ZnCl.sub.2 in MeOH or EtOH gave previously unknown 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles. |
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ISSN: | 0009-3122 1573-8353 |
DOI: | 10.1007/s10593-021-02940-4 |