Korean Red Ginseng Prevents the Deterioration of Lung and Brain Function in Chronic PM[sub.2.5]-Exposed Mice by Regulating Systemic Inflammation

This study was conducted to confirm the effects of Korean red ginseng on lung and brain dysfunction in a BALB/c mice model exposed to particulate matter (PM)[sub.2.5] for 12 weeks. Learning and cognitive abilities were assessed with Y-maze, passive avoidance, and Morris water maze tests. To evaluate...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 24; no. 17
Main Authors Kim, Ju Hui, Kim, Jong Min, Lee, Hyo Lim, Go, Min Ji, Kim, Tae Yoon, Joo, Seung Gyum, Lee, Han Su, Heo, Ho Jin
Format Journal Article
LanguageEnglish
Published MDPI AG 01.08.2023
Subjects
B cells
Brain
Inflammation
Prevention
South Korea
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Summary:This study was conducted to confirm the effects of Korean red ginseng on lung and brain dysfunction in a BALB/c mice model exposed to particulate matter (PM)[sub.2.5] for 12 weeks. Learning and cognitive abilities were assessed with Y-maze, passive avoidance, and Morris water maze tests. To evaluate the ameliorating effect of red ginseng extract (RGE), the antioxidant system and mitochondrial function were investigated. The administration of RGE protected lung and brain impairment by regulating the antioxidant system and mitochondrial functions damaged by PM[sub.2.5]-induced toxicity. Moreover, RGE prevented pulmonary fibrosis by regulating the transforming growth factor beta 1 (TGF-β1) pathway. RGE attenuated PM[sub.2.5]-induced pulmonary and cognitive dysfunction by regulating systemic inflammation and apoptosis via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)/c-Jun N-terminal kinases (JNK) pathway. In conclusion, RGE might be a potential material that can regulate chronic PM[sub.2.5]-induced lung and brain cognitive dysfunction.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms241713266