Intensity-Modulated Radiotherapy : an analysis of dose distribution and toxicities

• Published in: Radiation oncology (London, England) Vol. 10
• Main Authors: Yeung, Rosanna, McConnell, Yarrow, Warkentin, Heather, Graham, Darren, Warkentin, Brad, Joseph, Kurian, Doll, Corinne M
• Format: Journal Article
• Language: English
• Published: BioMed Central Ltd 17.04.2015
• Subjects: Cancer; Carcinoma; Care and treatment; Comparative analysis; Medical research; Medicine, Experimental; Mitomycin; Patient outcomes; Radiotherapy; Skin; Canada
• ISSN: 1748-717X; 1748-717X
• DOI: 10.1186/s13014-015-0398-4

Purpose Intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) have been adopted for radiotherapy treatment of anal canal carcinoma (ACC) due to better conformality, dose homogeneity and normal-tissue sparing compared to 3D-CRT. To date, only one published study compares dosimetric parameters of IMRT vs HT in ACC, but there are no published data comparing toxicities. Our objectives were to compare dosimetry and toxicities between these modalities. Methods and materials This is a retrospective study of 35 ACC patients treated with radical chemoradiotherapy at two tertiary cancer institutions from 2008-2010. The use of IMRT vs HT was primarily based on center availability. The majority of patients received fluorouracil (5-FU) and 1-2 cycles of mitomycin C (MMC); 2 received 5-FU and cisplatin. Primary tumor and elective nodes were prescribed to [greater than or equai to]54Gy and [greater than or equai to]45Gy, respectively. Patients were grouped into two cohorts: IMRT vs HT. The primary endpoint was a dosimetric comparison between the cohorts; the secondary endpoint was comparison of toxicities. Results 18 patients were treated with IMRT and 17 with HT. Most IMRT patients received 5-FU and 1 MMC cycle, while most HT patients received 2 MMC cycles (p < 0.01), based on center policy. HT achieved more homogenous coverage of the primary tumor (HT homogeneity and uniformity index 0.14 and 1.02 vs 0.29 and 1.06 for IMRT, p = 0.01 and p < 0.01). Elective nodal coverage did not differ. IMRT achieved better bladder, femoral head and peritoneal space sparing (V30 and V40, p [less than or equai to] 0.01), and lower mean skin dose (p < 0.01). HT delivered lower bone marrow (V10, p < 0.01) and external genitalia dose (V20 and V30, p < 0.01). Grade 2+ hematological and non-hematological toxicities were similar. Febrile neutropenia and unscheduled treatment breaks did not differ (both p = 0.13), nor did 3-year overall and disease-free survival (p = 0.13, p = 0.68). Conclusions Chemoradiotherapy treatment of ACC using IMRT vs HT results in differences in dose homogenity and normal-tissue sparing, but no significant differences in toxicities. Keywords: Anal cancer, Tomotherapy, Intensity modulated radiotherapy, Dosimetry, Toxicities