Four New Polyprenylated Acylphloroglucinols from IHypericum perforatum/I L

Hyperforatums A–D (1–4), four new polyprenylated acylphloroglucinols, together with 13 known compounds were isolated and identified from the aerial parts of Hypericum perforatum L. (St. John’s wort). Their structures were confirmed with a comprehensive analysis comprising spectroscopic methods, incl...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 8
Main Authors Wang, Xiaoying, Liu, Wuyang, Chen, Sheng, Gao, Yueshan, Tian, Junmian, Gao, Jinming
Format Journal Article
LanguageEnglish
Published MDPI AG 01.04.2024
Subjects
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Nervous system diseases
China
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Summary:Hyperforatums A–D (1–4), four new polyprenylated acylphloroglucinols, together with 13 known compounds were isolated and identified from the aerial parts of Hypericum perforatum L. (St. John’s wort). Their structures were confirmed with a comprehensive analysis comprising spectroscopic methods, including 1D and 2D NMR, HRESIMS, and electronic circular dichroism (ECD) calculations. Hyperforatum A featured an unusual chromene-1,4-dione bicyclic system, and hyperforatums B and C were two rare monocyclic PPAPs with five-membered furanone cores. Compound 1 exhibited a moderate inhibition effect on NO production in BV-2 microglial cells stimulated by LPS.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29081756