Huang Jin Shuang Shen granules can improve immunity and enhance the ability of 5-fluorouracil to induce apoptosis of gastric cancer cells

In recent years, Chinese herbal compounds have gained significant prominence in the treatment of gastric cancer. The goal of this study was to investigate the antitumor effect of HuangJinShuangShen granules (HJSS) combined with 5-fluorouracil on MFC gastric cancer mice. In this study, the MFC model...

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Bibliographic Details
Published inPakistan journal of pharmaceutical sciences Vol. 36; no. 6; p. 1759
Main Authors Xu, Xuefei, Yang, Chuqi, Wu, Mengting, An, Qingwen, Jiang, Tao, Zhang, Guangji
Format Journal Article
LanguageEnglish
Published Pakistan Journal of Pharmaceutical Sciences 01.11.2023
Subjects
Apoptosis
Dosage and administration
Drug synergism
Drug therapy
Fluorouracil
Immunity
Medicine, Chinese
Pharmaceutical research
Stomach cancer
China
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Summary:In recent years, Chinese herbal compounds have gained significant prominence in the treatment of gastric cancer. The goal of this study was to investigate the antitumor effect of HuangJinShuangShen granules (HJSS) combined with 5-fluorouracil on MFC gastric cancer mice. In this study, the MFC model with gastric cancer was successfully established. After continuous administration for 14 d, the body weight, tumor volume and weight, and spleen mass of mice in each group were recorded. The levels of IFN-[gamma] and TGF-[[beta].sub.1] in serum were detected by ELISA. The expression of apoptosis proteins in tumor tissues was detected by Western blotting. Compared with the model group and the 5-FU group, the combined drug group can significantly inhibit tumor growth, reduce tumor volume, promote tumor cell necrosis and increase spleen index in mice. At the same time, the combined treatment group significantly increased IFNY- [gamma] level and BAX protein expression, decreased TGF-[[beta].sub.1] level and decreased Bcl2, Caspase-9 and Cleaved Caspase-3 protein expressions. These findings provide evidence that HJSS can augment the suppressive impact of 5-FU on tumor growth in gastric cancer mice, potentially through the induction of tumor cell apoptosis and the restoration of immune function. Keywords: Gastric cancer, Huang Jin Shuang Shen granules, 5-fluorouracil, cell apoptosis, immunity.
ISSN:1011-601X
DOI:10.36721/PJPS.2023.36.6.REG.1759-1765.1