Methyl alcohol intoxication in Izmir: A retrospective analysis/Izmir'de metil alkol zehirlenmesi: Retrospektif analiz

• Published in: Türk nöroloji dergisi Vol. 30; no. 1; p. 31
• Main Authors: Uysal, Hasan Armagan, Gulluoglu, Halil, Kumcu, Muge Kuzu, Celik, Fatma Nazli Durmaz
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.03.2024
• Subjects: Alcohol; Health aspects; Methanol; Statistics; Turkey
• ISSN: 1301-062X; 1309-2545
• DOI: 10.55697/tnd.2024.47

Objectives: This study aimed to investigate methyl alcohol poisoning cases in Izmir. Patients and methods: The retrospective study included 15 patients (14 males, 1 female; mean age: 56.1[+ or -]9.3 years; range, 40 to 71 years) diagnosed with methyl alcohol poisoning due to counterfeit alcoholic beverage consumption between October 1, 2020, and October 30, 2020. Patients were grouped according to survival. The demographic and clinical data, including the Acute Physiology and Chronic Health Evaluation II scoring and Glasgow Coma Scale scores, were compared. Results: Of the patients, eight (53.3%) died, and seven survived. There was no significant difference between deceased and surviving patients regarding optical nerve involvement, mechanical ventilation need, and dyspnea (p=0.057, p=0.467, and p=0.467, respectively). On the other hand, a significant difference was observed between deceased and surviving patients regarding radiological imaging, visual impairment, gastrointestinal symptoms, and vasopressor agent need (p=0.044, p<0.001, p=0.011, and p=0.026, respectively). Mortality was significantly correlated with vasopressor agent needs, Acute Physiology and Chronic Health Evaluation II score, and Glasgow Coma Scale score (p=0.009; r=0.645, p=0.009; r=-0.652, p=0.008; and r=0.562, p=0.029; respectively). Conclusion: Methyl alcohol poisoning is a common and even accelerating problem in Türkiye and results in high mortality and morbidity. Clinical, social, and economic strategies should be developed by national authorities to combat the issue. Keywords: Alcohol consumption, methanol, poisoning. Amaç: Bu çalismada, Izmir'deki metil alkol zehirlenme vakalarinin incelemesi amaçlandi. Hastalar ve yöntemler: Bu retrospektif çalismaya 1 Ekim 2020-30 Ekim 2020 tarihleri arasinda sahte alkollü içecek tüketimi nedeniyle metil alkol zehirlenmesi tanisi konan 15 hasta (14 erkek, 1 kadin; ort. yas: 56,1[+ or -]9,3 yil; dagilim, 40-71 yil) dahil edildi. Hastalar sagkalima göre gruplandirildi. Akut Fizyoloji ve Kronik Saglik Degerlendirme II skorlamasi ve Glasgow Koma Skalasi skorlari dahil olmak üzere demografik ve klinik veriler karsilastirildi. Bulgular: Hastalardan sekizi (%53,3) öldü ve yedisi hayatta kaldi. Hayatini kaybeden ve hayatta kalan hastalar arasinda optik sinir tutulumu, mekanik ventilasyon ihtiyaci ve dispne açisindan anlamli bir fark yoktu (sirasiyla p=0,057, p = 0,467 ve p=0,467). Bununla birlikte, hayatini kaybeden ve hayatta kalan hastalar arasinda radyolojik görüntüleme, görme bozuklugu, gastrointestinal semptomlar ve vazopressör ajan ihtiyaci açisindan anlamli bir fark gözlendi (sirasiyla p=0,044, p<0,001, p=0,011 ve p=0,026). Mortalite; vazopressör ajan ihtiyaci, Akut Fizyoloji ve Kronik Saglik Degerlendirme II skoru ve Glasgow Koma Skalasi skoru ile anlamli bir sekilde iliskiliydi (sirasiyla p=0,009; r=0,645, p=0,009; r=-0,652, p=0,008; ve r=0,562, p=0,029). Sonuç: Metil alkol zehirlenmesi, Türkiye'de yaygin ve hatta artan bir sorun olup yüksek mortalite ve morbiditeye neden olmaktadir. Ulusal otoriteler tarafindan bu sorunun önüne geçmek için klinik, sosyal ve ekonomik stratejiler gelistirilmelidir. Anahtar sözcükler: Alkol tüketimi, metanol, zehirlenme.