Study of Lipid Profile in Pulmonary Tuberculosis Patients and Relapse Cases in Relation with Disease Severity -A Pilot Study

Malnutrition and Tuberculosis are synergistically associated to each other. Any inflammatory condition following infection causes release of free radicals and reactive oxygen species (ROS) which adversely affects host lipid by causing enhanced lipid peroxidation. The objective of the study was to de...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 29; no. S1; p. S117
Main Authors Taparia, Pallavi, Yadav, Dharmaveer, Koolwal, Suresh, Mishra, Sandhya
Format Journal Article
LanguageEnglish
Published Springer 01.12.2014
Subjects
Analysis
Blood lipids
Diseases
Health aspects
Low density lipoproteins
Medical research
Medicine, Experimental
Pulmonary tuberculosis
Relapse
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Summary:Malnutrition and Tuberculosis are synergistically associated to each other. Any inflammatory condition following infection causes release of free radicals and reactive oxygen species (ROS) which adversely affects host lipid by causing enhanced lipid peroxidation. The objective of the study was to determine the level of lipid fractions in newly diagnosed and relapsed Pulmonary Tuberculosis patients and to correlate serum lipid level with inflammation and disease severity. 32 newly diagnosed and 26 relapsed cases to PTB were recruited for the study. Patients were both male and female with average age 37.16 [+ or -] 1.2 years and 39.44 [+ or -] 1.5 years respectively. 25 age and gender matched healthy subjects that were non family members of patients were taken as controls for comparison. Fasting serum lipid profile Total Cholesterol (TC), Triglyceride (TG), HDL-cholesterol (HDL-C), Low density Lipoprotein (LDL) and Very Low density Lipoprotein (VLDL)) and CRP along with ADA were estimated. All lipid parameters were significantly (P<0.05) low in both newly diagnosed and relapse cases of Pulmonary Tuberculosis (PTB) than controls. TC and LDL level were significantly higher in relapsed patients than new PTB cases. Inflammatory markers (ADA and CRP) increased significantly (P<0.05) in both new and relapsed group according to control group. Cholesterol and LDL are moderately correlated to serum ADA as compared to CRP, however no significant correlation was observed between other lipid parameters with ADA or CRP. However, lipid parameters are well correlated with smear positivity extent (SPE) indicating that SPE is a better measure to assess disease severity which involves progressive decrease in serum lipids. Hypocholesterolemia exists in both newly diagnosed and relapse PTB patients and is one of the many nutritional factors predisposing for TB infection. Serum lipids affect overall strength of immune system with cholesterol being most widely studied in this aspect. SPE shows strong correlation with serum lipids in PTB patients, indicating its reliability in assessing dyslipidemia in PTB patients.
ISSN:0970-1915