Synthesis of 6-amino- and 6-hydroxy-1-aryl-2--1,2-dihydro-3H-pyrrolo[3,4-6]quinolin-3-ones

5-aryl-3-hydroxy-1-(thiazol-2-yl)-4-(2-thienoyl)-1,5-dihydro-2H-pyrrol-2-ones were found to react with meta-phenylenediamine or 3-aminophenol forming pyrrolo[3,4-b]quinolin-3-ones. Using 4-aminophenol and 3-methoxyaniline as reagents led to the formation of 3-arylamino derivatives. The identity of t...

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Published inChemistry of heterocyclic compounds (New York, N.Y. 1965) p. 1692
Main Authors Gein, V.L, Maryasov, M.A, Gein, L.F
Format Journal Article
LanguageEnglish
Published Springer 01.03.2015
Subjects
Anti-arrhythmia drugs
Nuclear magnetic resonance spectroscopy
Quinoline
Resveratrol
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Summary:5-aryl-3-hydroxy-1-(thiazol-2-yl)-4-(2-thienoyl)-1,5-dihydro-2H-pyrrol-2-ones were found to react with meta-phenylenediamine or 3-aminophenol forming pyrrolo[3,4-b]quinolin-3-ones. Using 4-aminophenol and 3-methoxyaniline as reagents led to the formation of 3-arylamino derivatives. The identity of the obtained products was confirmed by IR, ¹H and [sup.13]C NMR spectroscopy and mass spectrometry. Keywords: 3-aminophenol, 4-aminophenol, 3-hydroxy-3-pyrrolin-2-ones, 3-methoxyaniline, metaphenylenediamine, pyrrolo[3,4-b]quinolin-3-ones, binucleophiles.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-015-1639-z