Axillary Lymph Node Uptake on [.sup.18]F-FDG PET/CT after COVID-19 Vaccination: A Direct Comparison Study with Influenza Vaccination/COVID-19 Asisindan Sonra [.sup.18]F-FDG PET/BT'de Aksiller Lenf Nodu Tutulumu: Grip Asisi ile Dogrudan Karsilastirma Calismasi

• Published in: Molecular imaging and radionuclide therapy Vol. 32; no. 1; p. 13
• Main Authors: Otomi, Yoichi, Shinya, Takayoshi, Kasai, Hiroto, Okada, Naoko, Matsushita, Tomoki, Higashi, Kohei, Matsuzaki, Saya, Hiroshima, Yuka, Kubo, Michiko, Otsuka, Hideki, Harada, Masafumi
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.02.2023
• Subjects: Comparative analysis; CT imaging; Immune response; Influenza vaccines; Lymph nodes; Medical examination; PET imaging; Japan
• ISSN: 2146-1414
• DOI: 10.4274/mirt.galenos.2022.27136

Objectives: To compare vaccinated-side axillary lymph node uptake on [.sup.18]F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) after coronavirus disease-2019 (COVID-19) and influenza vaccination. Methods: We retrospectively analyzed 177 patients who underwent [.sup.18]F-FDG PET/CT after COVID-19 or influenza vaccination. We compared the uptake of the vaccinated-side axillary lymph nodes of 109 COVID-19 vaccinated patients with those of a lot of influenza-vaccinated patients. We also compared the uptake between 66 patients who received the first COVID-19 vaccination with 43 who received the second COVID-19 vaccination. Results: [.sup.18]F-FDG-avid axillary lymph nodes on the vaccinated side were significantly more frequently observed in the COVID-19 group (45%) than in the influenza group (19%) (p<0.001). When the interval between vaccination to PET/CT was within 7 days, there was no significant difference in the frequency of [.sup.18]F-FDG-avid vaccinated-side axillary lymph nodes between the groups (COVID-19 group: 41% vs. influenza group: 45%, p=D.724). When the interval was over 7 days, [.sup.18]F-FDG-avid lymph nodes were much more frequent in the COVID-19 group (47%) than in the influenza group (7%) (p<0.001). Comparing the first and second COVID-19 groups, [.sup.18]F-FDG-avid lymph nodes were more frequent in the second vaccination group than in the first vaccination group, but the difference was not significant. Conclusion: [.sup.18]F-FDG-avid vaccinated-side axillary lymph nodes were more frequently observed in the COVID-19 group than in the influenza group. In the case of the COVID-19 vaccine, a delay of [.sup.18]F-FDG PET/CT examination is recommended by a longer interval from vaccination than in the influenza vaccine. Keywords: COVID-19, influenza, vaccination, [.sup.18]F-FDG PET/CT, axillary lymph node Amac: Koronavirus hastaligi-2019 (COVID-19) asisi ve grip asisi sonra [.sup.18]F-florodeoksiglukoz (FDG) pozitron emisyon tomografisi/bilgisayarli tomografi (PET/BT) ile asilanan taraf aksiller lenf nodu tutulumunu karsilastirmaktir. Yontemler: COVID-19 veya influenzaya yonelik asilamadan sonra [.sup.18]F-FDG PET/BT uygulanan 177 hastayi retrospektif olarak inceledik. COVID-19 asisi yapilan 109 hastanin asilanmis taraftaki aksiller lenf nodlarindaki [.sup.18]F-FDG tutulumunu, grip asisi yapilan hastalardaki tutulum ile karsilastirdik. Ayrica ilk COVID-19 asisini olan 66 hasta ile ikinci COVID-19 asisini olan 43 hasta arasindaki alimi karsilastirdik. Bulgular: Asilanan taraftaki [.sup.18]F-FDG tutulumu olan aksiller lenf nodlari, COVID-19 grubunda (%45) influenza grubuna (%19) gore anlamli derecede daha sik gozlendi (p<0,001). PET/BT ile asilama arasindaki aralik 7 gun icinde oldugunda, gruplar arasinda [.sup.18]F-FDG tutulumu olan asili taraf aksiller lenf nodu sikliginda anlamli bir fark yoktu (COVID-19 grubu: %41 vs. influenza grubu: %45, p=0,724). Aralik 7 gunden fazla oldugunda, [.sup.18]F-FDG tutulumlu lenf nodlari, COVID-19 grubunda (%47) influenza grubuna (%7) gore cok daha sikti (p<0,001). Birinci ve ikinci COVID-19 gruplari karsilastirildiginda, [.sup.18]F-FDG tutulumlu lenf nodlari ikinci asilama grubunda birinci asilama grubuna gore daha sikti ancak aradaki fark anlamli degildi. Sonuc: [.sup.18]F-FDG tutulumlu asilanmis taraf aksiller lenf nodlari, COVID-19 grubunda influenza grubuna gore daha sik gozlendi. COVID-19 asisi soz konusu oldugunda, [.sup.18]F-FDG PET/BT incelemesinin, grip asisina gore daha uzun bir aralikla ertelenmesi onerilir. Anahtar Kelimeler: COVID-19, influenza, asilama, [.sup.18]F-FDG PET/BT, aksiller lenf nodu