Visfatin as a predictor for growth of fetus and infant/Fetus ve bebegin buyumesi icin bir on gordurucu olarak visfatin

• Published in: Turkish journal of obstetrics and gynecology Vol. 15; no. 2; p. 80
• Main Authors: Taraqi, Ashraf Saber Mashhad, Tehranian, Najmeh, Aghoozi, Marzieh Faghani, Yousefi, Somayeh, Kazemnejad, Anoshirvan, Roudbaneh, Shiva Pourali, Esmaeilzadeh, Matin Sadat
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.06.2018
• Subjects: Analysis; Body mass index; Cytokines; Fetus; Gene expression; Health aspects; Pregnant women
• ISSN: 2149-9322
• DOI: 10.4274/tjod.48091

Objective: Visfatin is an adipocytokine that functions as an enzyme and a growth factor to investigate the relationship between serum visfatin and the fetus's anthropometric markers up to a year after birth. Materials and Methods: Forty-one eligible pregnant women in their frst trimester were divided and matched in terms of body mass index (BMI) before pregnancy into normal and higher than normal BMI groups, A and B. Serum visfatin levels were measured during 6-12 and 15-20 weeks of gestation using ELISA. Results: The infants were followed up for a mean duration of 10.19[+ or -]2.83 months. In group A, there was a strong positive relationship between birth head circumference and the frst (p =0.054, [r.sub.1]=0.580) and second trimester visfatin levels (p =0.051, [r.sub.2]=0.530). In group B, second trimester visfatin levels correlated negatively with birth length (p=0.015, r=-0.523) and infant's head circumference (p =0.050, r =-0.392). In a separate study on group B, visfatin levels in the frst and second trimesters showed a significant negative correlation with infant's weight. A significant correlation was observed between the frst and second trimesters visfatin level with infant's height in both groups, such that this relationship was positive in group A and negative in group B. Linear regression analysis revealed that frst and second trimester visfatin levels were significant independent predictors of infant's weight in group B and infant's height in both groups. Second trimester visfatin level was a significant predictor of birth height in group B. Conclusion: Maternal serum visfatin level shows a relationship with fetal and infant anthropometric indicators, with different effects in the two groups, suggesting visfatin dysfunction in the overweight group before pregnancy Keywords: Visfatin, predictor, grow, fetus, infant Giris: Visfatin, sadece enzim olarak degil ayni zamanda bir buyume faktoru olarak da islev goren bir adipositokindir. Bu calisma, serum visfatin ile fetusun antropometrik belirtecleri arasindaki iliskinin dogumdan sonraki bir yila kadar arastirilmasi amaciyla yurutulmustur. Gerec ve Yontemler: Birinci trimesterdeki 41 uygun gebe kadin, beden kitle indeksi (BKI) acisindan normal ve normal BKI'den daha yuksek olmak uzere grup A ve B olarak ayrildi ve eslestirildi. Serum visfatin duzeyi gebeligin 6-12 ve 15-20 haftalarinda ELISA yontemi kullanilarak olculdu. Bulgular: Cocuklar, ortalama 10,19[+ or -]2,83 ay suresince takip edildi. A grubunda, dogum basi cevresi ile birinci ([p.sub.1]=0,054, [r.sub.1]=0,580) ve ikinci trimester visfatin duzeyleri ([p.sub.2]=0,051, [r.sub.2]=0,530) arasinda neredeyse pozitif anlamli bir iliski gozlendi. B grubunda, ikinci trimester visfatin duzeyi, dogum boyu (p=0,015, r=-0,523) ve bebegin bas cevresi [neredeyse anlamli ([p.sub.2]=0,050, [r.sub.2]=-0,392)] ile negatif iliskilendirildi. B grubu uzerinde yapilan ayri bir calismada, birinci ve ikinci trimester visfatin duzeyleri bebegin agirligi ile negatif anlamli bir korelasyon gosterdi. Her iki grupta da bebegin boyu ile birinci ve ikinci trimester visfatin duzeyi arasinda anlamli bir korelasyon gozlendi, oyle ki bu iliski A grubunda pozitif ve B grubunda negatif idi. Dogrusal regresyon analizi; birinci ve ikinci trimesterdeki visfatin duzeylerinin, B grubundaki bebek agirliginin ve her iki gruptaki bebek boylarinin anlamli bagimsiz on gordurucu oldugunu ortaya cikarmistir. Ikinci trimester visfatin duzeyi, B grubundaki dogum boyunun anlamli bir on gordurucusuydu. Sonuc: Annenin serum visfatin duzeyi, fetus ve cocugun antropometrik belirtecleri ile iki grupta farkli etkilerle, gebelik oncesi fazla kilolu grupta visfatin disfonksiyonunu dusunduren bir iliski gostermektedir. Anahtar Kelimeler: Visfatin, on gordurucu, buyume, fetus, bebek PRECIS: We measured the serum visfatin level in pregnancy, and assess its relationship with the children's anthropometric markers, to determine if it can be used as biomarker.