Index as a New Measure of Disease Status in Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic polyarthritis and bone destruction. B cells are implicated in the inflammatory events of RA by producing antibodies and a polyclonal excess of serum free light chains kappa (K) and lambda (L). Thus, the...

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Published inIndian journal of clinical biochemistry Vol. 34; no. S1; p. S163
Main Authors Noorjahan, M, Baba, KSS Sai, Pradeep, J, Deepika, Y. Lakshmi, Rajashekar, Liza
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Analysis
Arthritis
B cells
Rheumatoid factor
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Summary:Rheumatoid Arthritis (RA) is a systemic inflammatory autoimmune disease characterized by chronic polyarthritis and bone destruction. B cells are implicated in the inflammatory events of RA by producing antibodies and a polyclonal excess of serum free light chains kappa (K) and lambda (L). Thus, the sum of the serum levels of K and L reflects B cells activation and the inflammatory activity of the RA. This study aims to compare the (K+L) index between healthy controls and RA patients, to compare between seropositive (SP) and seronegative (SN) RA patients and also to correlate (K+L) index with ACR2010 score (criteria for earlier diagnosis of RA) and inflammatory marker hsCRP. Study is based on 68 subjects (24 SN, 19 SP and 25 healthy controls) with a mean age of 44.2 [+ or -] U years (F:M=57:11). Disease activity of RA was evaluated using ACR 2010 score. The cases included were having a score of [greater than or equal to] 6 indicating active disease. Serum free light chains Kappa and Lambda were analyzed by using mmunoturbidimetry method (Binding site kits, UK) and hsCRP was analyzed also by immunoturbidimetry method. Serum levels of (K+L) index in patients with RA were significantly higher than healthy controls, 66.0 (59.0-69.39) vs 36.28-40.85) mg/L respectively (p<0.0001). The area under curve was 0.94 (95% CI: 0.872 to 1.00). However there is no difference between SP and SN cases. A good linear correlation was found for (K+L) index with ACR 2010 SCORE (r=0.63; p<0.0001) and hsCRP (r=0.469; p<0.0004). The levels of serum "(K+L) index" could be useful to differentiate RA cases from healthy controls. However it is not useful to discriminate between SN and SP. The (K+L) index was found to be associated with disease severity as well as inflammation.
ISSN:0970-1915