Synthesis of New BisMethanes Catalyzed by Benzylsulfamic Acid and Evaluation of Their Antimicrobial Activities

Benzylsulfamic acid has been prepared and introduced as a new heterogeneous acid catalyst. This reagent was used for the synthesis of new bis(indolyl)methanes 3a - 3f via reaction of bis-aldehydes 1 with indoles 2 at 100°C. All reactions were performed under solvent-free conditions with high to exce...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 53; no. 10; p. 947
Main Authors Soltani, Sara, Montazeri, Naser, Zeydi, Masoud Mohammadi, Heravi, Majid M
Format Journal Article
LanguageEnglish
Published Springer 01.01.2020
Subjects
Antibacterial agents
Chemical tests and reagents
Methane
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Summary:Benzylsulfamic acid has been prepared and introduced as a new heterogeneous acid catalyst. This reagent was used for the synthesis of new bis(indolyl)methanes 3a - 3f via reaction of bis-aldehydes 1 with indoles 2 at 100°C. All reactions were performed under solvent-free conditions with high to excellent yields. The synthesized bis(indolyl)methanes were evaluated for their antibacterial and antifungal activities.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-020-02103-3