The Structural, Crystallinity, and Thermal Properties of pH-responsive Interpenetrating Gelatin/Sodium Alginate-based Polymeric Composites for the Controlled Delivery of Cetirizine HCl/Setirizin HCl'nin Kontrollu Salimi icin pH Duyarli Interpenetrasyon Jelatin/Sodyum Aljinat-esasli Polimerik Kompozitlerin Yapi, Kristalinite ve Termal Ozellikleri

• Published in: Turkish Journal of Pharmaceutical Sciences Vol. 15; no. 1; p. 63
• Main Authors: Afzal, Samrin, Khan, Samiullah, Ranjha, Nazar Mohammad, Jalil, Aamir, Riaz, Amina, Haider, Malik Salman, Sarwar, Shoaib, Saher, Fareha, Naeem, Fahad
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.04.2018
• Subjects: Cetirizine; Dosage and administration; Drug delivery systems; Pharmaceutical research; Testing
• ISSN: 1304-530X
• DOI: 10.4274/tjps.64326

Objectives: The present work aimed to design and synthesize pH-sensitive cross-linked Ge/SA hydrogels using different ratios of each polymer, and to investigate the effect of each polymer on dynamic, equilibrium swelling, and in vitro release pattern of cetirizine hydrochloride, which was selected as a model drug. Materials and Methods: These gelatin and sodium alginate hydrogels were prepared at room temperature through free radical polymerization using glutaraldehyde as a crosslinker. These polymeric composites were used as model systems to envisage various important characterizations. The in vitro release pattern of drug was investigated in three different mediums (phosphate buffer solution of pH 1.2, 5.5, 7.5 whose ionic strength was kept constant). Various structure property relationships that affect its release behavior were determined such as swelling analysis, porosity, solgel analysis, average molecular weight between crosslinks (Mc), solvent interaction parameter ([chi]), volume fraction of polymer ([V.sub.2,s]) and diffusion coefficient. The structural, crystallinity, and thermal stability were confirmed using FTIR, XRD, and DSC analysis. Results: These hydrogels showed maximum swelling at pH 1.2. Zero-order, first-order, Higuchi, and Peppas models were applied to demonstrate the release pattern of drug. The release of drug occurred through non-Fickian diffusion or anomalous mechanism. Porosity was found increased with an increase in concentration of both polymers, and porosity decreased when the concentration of the crosslinker was increased. Gel fraction increased with an increase in concentration of SA, Ge, and glutaraldehyde. Conclusion: The prepared pH sensitive hydrogels can be used as a potential carrier for the sustained delivery of cetirizine hydrochloride. Key words: pH responsive, dynamic swelling, cetirizine HCl, in vitro release, controlled delivery Amac: Bu calismada, her bir polimerin farkli oranlari kullanilarak pH duyarli capraz bagli jelatin/sodyum aljinat hidrojellerinin tasarlanmasi ve sentezlemesi ve her bir polimerin dinamik, kararli sisme ve model etken madde olarak secilen setirizin hidroklorurun in vitro salim profiline etkisinin arastirilmasi amaclanmistir. Gerec ve Yontemler: Bu jelatin ve sodyum aljinat hidrojelleri, oda sicakliginda, capraz baglayici olarak glutaraldehitin kullanimiyla serbest radikal polimerizasyonu ile hazirlandi. Bu polimerik kompozitler, cesitli onemli karakterizasyonlari ongormek icin model sistemler olarak kullanildi. Etken maddelerin in vitro salim modeli uc farkli ortamda (pH 1.2, 5.5, 7.5 iyonik kuvveti sabit tutulan fosfat tampon cozeltisi) arastirildi. Solunum analizi, gozeneklilik, sol-jel analizi, capraz baglar arasindaki ortalama molekul agirligi (Mc), cozucu etkilesim parametresi ([chi]), polimerin hacim fraksiyonu ([V.sub.2,s]) ve difuzyon gibi salim davranisini etkileyen cesitli yapi ozellik iliskileri belirlendi. FTIR, XRD ve DSC analizi kullanilarak yapi, kristalinite ve termal stabilite dogrulandi. Bulgular: Bu hidrojeller pH 1.2'de maksimum sisme gosterdi. Etken madde salim modelini gostermek icin sifir derece, birinci derece, Higuchi ve Peppas modelleri uygulandi. Etken madde salimi, non-Fick difuzyon veya anomolus mekanizmasiyla gerceklesti. Her iki polimer konsantrasyonundaki artisla porozitenin arttigi ve capraz baglayici konsantrasyonu arttikca gozenekliligin azaldigi bulundu. Sodyum aljinat, jelatin ve glutaraldehit konsantrasyonunda artis ile jel fraksiyonu artmistir. Sonuc: Hazirlanan pH'ya duyarli hidrojeller, setirizin hidroklorur surekli salimi icin potansiyel bir tasiyici olarak kullanilabilir. Anahtar kelimeler: pH'ya duyarli, dinamik sisme, setirizin HCI, in vitro salim, kontrollu salim