New Azido Coumarins as Potential Agents for Fluorescent Labeling and Their “Click” Chemistry Reactions for the Conjugation with Icloso/I-Dodecaborate Anion

Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained c...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 27; no. 23
Main Authors Laskova, Julia, Serdyukov, Alexander, Kosenko, Irina, Ananyev, Ivan, Titova, Ekaterina, Druzina, Anna, Sivaev, Igor, Antonets, Anastasia A, Nazarov, Alexey A, Bregadze, Vladimir I
Format Journal Article
LanguageEnglish
Published MDPI AG 01.12.2022
Subjects
Cells
Coumarins
Labeling
United States
United Kingdom
Russia
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Summary:Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained coumarins have been tested with closo-dodecaborate derivative bearing terminal alkynyl group. Cu[sup.I] catalyzed Huisgen 1,3-dipolar cycloaddition reaction has led to fluorescent conjugates formation. The absorption-emission spectra of the formed conjugates have been presented. The antiproliferative activity and uptake of compounds against several human cell lines were evaluated.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238575