Analysis of 65 Years Old and Over Patients with Full Dose Vaccination by Inactive Vaccine and without Vaccination Admitted to Hospital with SARS-Cov-2 PCR Positivity/SARS-Cov-2 PCR Pozitifligi Nedeniyle Hastaneye Yatan 65 Yas ve Uzeri Tam Doz Inaktif Asili ve Asisiz Olgularin Irdelenmesi

• Published in: KLIMIK dergisi Vol. 35; no. 2; p. 64
• Main Authors: Ersan, Gursel, Rollas, Kazim, Atalay, Sabri, Singil, Sarp, Mert, Kamil, Abakay, Hilal, Senoglu, Nimet, Serin-Senger, Suheyla, Kose, Sukran
• Format: Journal Article
• Language: English
• Published: DOC Design and Informatics Co. Ltd 01.08.2022
• Subjects: Analysis; China; Comorbidity; Coronaviruses; Medical research; Medicine, Experimental; Mortality; Pharmaceutical industry; Severe acute respiratory syndrome; United States; Vaccination; United States; China
• ISSN: 1301-143X; 1309-1484
• DOI: 10.36519/kd.2022.4138

Objective: In this study, we aimed to analyze real-time reverse transcription-polymerase chain reaction (RT-PCR) positive elderly patients ([greater than or equal to] 65 years old) admitted to the hospital with symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection regarding their vaccination status. Methods: The study included 151 COVID-19 patients aged > 65 years old, admitted to the hospital between March 10 and June 30, 2021. The study group was divided into two groups: Group 1 consisted of patients who had two doses of inactive vaccine, administered at four weeks interval, and Group 2 consisted of unvaccinated patients who had no vaccination at all or got one dose of vaccine or had an infection within 15 days of completion of the vaccination schedule. We compared the two groups based on demographic, clinical, laboratory, and mortality data. Results: Groups 1 and 2 included 78 and 73 patients, respectively. There was no significant difference between groups regarding gender distribution, age, intensive care admission, number of underlying diseases, and laboratory and radiological findings. However, the number of comorbidities and mortality showed a significant positive correlation. Also, the presence of desaturation was significantly associated with mortality. Conclusion: In this study, we established that an inactive virus vaccine had no significant protectivity for the severity of disease and mortality in the elderly population. Keywords: Elderly population, COVID-19, inactive COVID-19 vaccines Amac: Calismada, 65 yas ve ustu semptomatik seyirli, gercek zamanli revers transkriptaz polimeraz zincir reaksiyonu (RT-PCR) teknigi ile agir akut solunum sendromu koronavirus 2 (SARS-CoV-2) pozitifligi saptanan ve hastaneye yatirilan olgularin asilanma durumlarina gore irdelenmesi amaclandi. Yontemler: Calismaya, 10 Mart--30 Haziran 2021 tarihleri arasinda COVID-19 tanisi ile hastanemize yatan 65 yas ustu 151 olgu dahil edildi. Olgular asili (Grup 1) ve asisiz (Grup 2) olmak uzere iki grupta incelendi. Grup 1, dort hafta ara ile iki doz inaktive asi olup asilarinin tamamlanmasindan 15 gun sonra hasta olanlardan olusurken; Grup 2, hic asi olmayanlar, bir doz asi olanlar veya iki doz asi olan ancak ikinci dozun uzerinden 15 gun gecmeden hasta olanlardan olustu. Gruplar demografik ve klinik ozellikler, laboratuvar verileri ve mortalite yonunden kiyaslandi. Bulgular: Calismaya alinan 151 olgunun 78'i Grup 1de, 73'u Grup 2de yer aldi. Gruplar arasinda cinsiyet dagilimi, yas ortalamasi, asilanma, yogun bakimda izlenme, ek hastalik, mortalite, laboratuvar ve goruntuleme yonunden anlamli farklilik saptanmadi. Ek hastalik sayisi ve mortalitenin yani sira desaturasyon ile mortalite arasinda anlamli korelasyon saptandi. Sonuclar: Calismamizda, ulkemizde uygulanan inaktif virus asisinin yasli populasyonu agir hastalik ve olumden korumadigi tespit edildi. Anahtar sozcukler: Yasli populasyon, COVID-19, inaktive COVID-19 asisi