Reproductive Functions in Male Patients with Epilepsy Epilepsi Tanili Erkek Hastalarda Üreme Fonksiyonlari

• Published in: Türk nöroloji dergisi Vol. 27; no. 4; p. 394
• Main Authors: Çubuk, Can, Peköz, Mehmet Taylan, Bozdemir, Hacer, Aslan, Kezban
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.12.2021
• Subjects: Complications and side effects; Epilepsy; Impotence; Risk factors; Turkey
• ISSN: 1301-062X; 1309-2545
• DOI: 10.4274/tnd.2021.04934

Objective: Hormonal changes and abnormalities in reproductive function may occur in patients with epilepsy. This study aimed to investigate the abnormalities in the reproductive functions in male patients with epilepsy under antiepileptic treatment and its negative impact on their children. Materials and Methods: A total of 104 participants were included in the study, wherein 52 were patients and 52 were healthy controls. Medical history and completed neurological examination were performed on all participants. Each participant filled out the International Index of Erectile Function (IIEF) and Beck depression scale. Serum hormones and biochemistry tests were also checked. Electroencephalography that was performed within the last 6 months and cerebral imaging anytime during the follow-up period were retrospectively evaluated. The Statistical Package for the Social Sciences 20.0 program was used for statistical evaluation. Results: The mean age of the male patients with epilepsy was 29.1[+ or -]5.5 years. The prevalence of erectile dysfunction was 63.5% in male patients with epilepsy, and 40.4% of the patients developed erectile dysfunction after antiepileptic drug use. Patients on polytherapy were found to have a higher risk of depression. Furthermore, patients with intractable seizures were more depressed (p=0.044). Beck scale and IIEF scores negatively affected each other (rs: -0.568). Patients with polytherapy have higher estrogen levels, whereas the luteinizing hormone levels were lower. Congenital malformation percentage is defined by 4.2% in children of male patients with epilepsy. Two of them have atrial septal defects and 1 with foramen ovale. Conclusion: The possibility of congenital malformation and abnormalities in the children of male patients with epilepsy should not be overlooked. Patients and their relatives should be provided with the necessary support and information after careful risk assessment. Keywords: Epilepsy, seizure, hormone, congenital malformation Amaç: Epilepsi hastalarinda hormonal degisiklikler ve üreme fonksiyonunda anormallikler meydana gelebilmektedir. Bu çalismanin amaci, antiepileptik tedavi alan epilepsi tanili erkek hastalarin üreme islevlerindeki anormalliklerin ve bu hastalarin çocuklarinda olumsuz etkilerinin arastirilmasidir. Gereç ve Yöntem: Çalismaya 52 hasta ve 52 saglikli kontrol olmak üzere toplam 104 kisi dahil edilmistir. Tüm katilimcilarin tibbi öyküleri alindi ve nörolojik muayeneleri yapildi. Çalismaya katilan her bir kisi Uluslararasi Erektil Islev Formu (IIEF) ve Beck depresyon ölçegini doldurdu. Serum hormon ve biyokimyasal testleri yapildi. Son alti ay içerisinde yapilan elektroensefalografi ve takibi süresince herhangi bir zamanda yapilan serebral görüntüleme bulgulari retrospektif olarak degerlendirildi. Verilerin istatistiksel analizi için SPSS programi 20.0 sürüm kullanildi. Bulgular: Erkek epilepsi hastalarinin yas ortalamasi 29,1[+ or -]5,5'ti. Epilepsi tanili erkek hastalarda erektil disfonksiyon prevalansi %63,5 olarak degerlendirildi. Hastalarin %40,4'ünde antiepileptik ilaç tedavisi sonrasi erektil disfonksiyon gelistigi saptandi. Politerapi alan hastalarin depresyon açisindan daha yüksek risk altinda oldugu saptandi. Ayrica, kontrolsüz nöbetleri olan hastalarin daha depresif oldugu görüldü (p=0,044). Beck depresyon ölçegi ve IIEF skorlarinin ters orantili oldugu belirlendi (rs: -0,568). Politerapi alan hastalarda östrojen seviyeleri daha yüksek, luteinize edici hormon seviyeleri daha düsüktü. Erkek epilepsi hastalarinin çocuklarinda konjenital malformasyon orani %4,2 olarak saptandi. Konjenital malformasyonlardan iki tanesi atriyal septal defekt olup bir tanesi de patent foramen ovale olarak degerlendirildi. Sonuç: Epilepsi tanili erkek hastalarin çocuklarinda konjenital malformasyon ve anormallik gelisme olasiligi göz ardi edilmemelidir. Dikkatli bir risk degerlendirmesi sonucunda hasta ve yakinlarina gerekli destek ve bilgi yol gösterici alacaktir. Anahtar Kelimeler: Epilepsi, nöbet, hormon, konjenital malformasyon