Association of 25--Vitamin D with Lipid Profile Among Poor Glycaemic Control Type II Diabetes Patient

25-(OH)- vitamin D has a significant role to minimize chronic metabolic syndromes and cardiovascular disease in type 2 diabetes mellitus patient. 25-(OH)-D down-regulates the serum lipid by lipogenesis. However, studies between relationships between 25-(OH)-D are inadequate. We aimed to evaluate the...

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Bibliographic Details
Published inIndian journal of clinical biochemistry Vol. 34; no. S1; p. S179
Main Authors Pokhrel, Sushant, Giri, Nisha, Pokhrel, Rakesh
Format Journal Article
LanguageEnglish
Published Springer 24.05.2022
Subjects
Alfacalcidol
Blood sugar
Calcifediol
Diabetes therapy
Diet therapy
Medical research
Medicine, Experimental
Type 2 diabetes
Vitamin D
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Summary:25-(OH)- vitamin D has a significant role to minimize chronic metabolic syndromes and cardiovascular disease in type 2 diabetes mellitus patient. 25-(OH)-D down-regulates the serum lipid by lipogenesis. However, studies between relationships between 25-(OH)-D are inadequate. We aimed to evaluate the association between 25-(OH)-D and serum lipid in poor glycaemic control type 2 diabetic Nepalese populations. This cross-sectional study was carried out among 247 poor glycaemic control diabetes patients attended in Modern Diagnostic and Research Center. Sociodemographic data and anthropometric measurements were recorded using a standard questionnaire. Fasting plasma glucose, HbA1c and Vitamin D3 & Vitamin B12 were estimated by Dimension RxL Max Chemistry Analyser, Lefetronic-H9 Hemoglobin Analyser, and Advia Centaur XP Immunoassay. Student's t-test, One-way Anova test, Mann-Whitney U test, and Kruskal Wallis test were used for comparison between different groups and the correlation was established by Spearman's correlation. The median serum 25-(OH)-D level was 17.89 ng/ml, and the prevalence of hypovitaminosis was 83%. Serum 25 (OH)D deficient patients had a significantly higher level of Fasting blood sugar, Total cholesterol (TC), Triglyceride (TG), and Non-HDL-C (p <0.05). Atherogenic variables such as Cardiac risk ratio, Atherogenic coefficient, Atherogenic index plasma and TC, TG and non-HDL-C shows significantly negative correlation with serum vitamin D level. Serum Vitamin D level shows a negative correlation with lipid profile. Vitamin D supplementation may reduce the risk of cardiovascular complication among type 2 diabetic population.
ISSN:0970-1915
0974-0422