Isolation and Characterization of Antimicrobial Metabolites from the ISophora tonkinensis/I-Associated Fungus IPenicillium/I sp. GDGJ-N37

Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3–6), together with two new chromone derivatives, penithochro...

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Published inMolecules (Basel, Switzerland) Vol. 29; no. 2
Main Authors Huang, Lili, Li, Yongxia, Pang, Jing, Lv, Liuxia, Zhou, Jiatong, Liang, Liqi, He, Xianhua, Li, Jun, Xu, Weifeng, Yang, Ruiyun
Format Journal Article
LanguageEnglish
Published MDPI AG 01.01.2024
Subjects
Dysentery
Fungi
Metabolites
Methicillin
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Summary:Chemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3–6), together with two new chromone derivatives, penithochromones X and Y (7 and 8). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis. Sclerotioramine (3) showed significant antibacterial activities against B. subtilis and S. dysentery, and it also showed most potent anti-plant pathogenic fungi activities against P. theae, C. miyabeanus, and E. turcicum.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29020348