The creatine peak administration do not alter glucose homeostasis and decreases food intake in rats/O uso de creatina pico nao altera a homeostase glicemica e diminui a ingestao alimentar de ratos

• Published in: Revista brasileira de nutrição esportiva Vol. 8; no. 47; p. 307
• Main Authors: Vieira, Roberto Carlos, Jr, de Araujo, Michel Barbosa, Costa, Marcelo, Jr, Dalia, Rodrigo Augusto, Voltarelli, Fabricio Azevedo
• Format: Journal Article
• Language: Portuguese
• Published: Instituto Brasileiro de Pesquisa e Ensino em Fisiologia do Exercicio. IBPEFEX 01.09.2014
• Subjects: Carbohydrate metabolism; Creatine; Dextrose; Glucose; Homeostasis; Physiological aspects; Water balance (Hydrology)
• ISSN: 1981-9927; 1981-9927

The present study verified glucose homeostasis as well as water and food intakes of rats fed in a diet adding creatine. Ten male Wistar rats were subjected to cross-over test and fed a diet added creatine in saturated phase cell (peak) (AIN-93M + 13% of creatine) or a standard diet (AIN-93M). Body weight and water and food intakes were recorded five days/week; at the end of each period of creatine administration (10 days) the animals performed GTT and ITT tests. The creatine administration in the phase peak did not alter glucose homeostasis, increased water intake and decreased food intake. Further studies are required in order to verify how the creatine administration in the phase peak may change the water balance, the intra and extracellular osmolality, and even the mechanisms of thirst, hunger and satiety, which are modulated by hypothalamus. Key words: Creatine. Carbohydrate Metabolism. Rats. O presente estudo verificou a homeostase glicemica e as ingestoes hidricas e alimentar de ratos alimentados ou nao com dieta acrescida de creatina. Dez ratos Wistar machos foram submetidos ao ensaio tipo cross-over e alimentados com dieta acrescida de creatina em fase de saturacao celular (pico) (AIN-93M + 13% de creatina) ou dieta padrao (AIN-93M). Peso corporal e ingestoes hidrica e alimentar foram registrados cinco dias/semana; ao final de cada periodo de administracao da creatina (10 dias) os animais realizaram o GTT e o ITT. A creatina em fase pico nao alterou a homeostase glicemica dos animais, aumentou a ingestao hidrica e diminuiu a ingestao alimentar. Estudos futuros sao requeridos para verificar ate que ponto a administracao de creatina, em diferentes formas, altera de forma significativa o balanco hidrico, a osmolaridade intra e extracelular e, ate mesmo, os mecanismos de sede, fome e saciedade, os quais sao modulados pelo hipotalamo. Palavras-chave: Creatina. Metabolismo dos Carboidratos. Ratos.