Demographic findings of patients diagnosed with pernio and comparison of their vitamin B12, folate and ferritin levels with a control group/ Pernio tanisi konulan hastalarin demografik bulgularinin incelenmesi ve BI2 vitamin, folat ve ferritin duzeylerinin kontrol grubu ile karsilastirilmasi

• Published in: Türkderm Vol. 53; no. 3; p. 88
• Main Authors: Karagun, Ebru, Baysak, Sevim
• Format: Journal Article
• Language: Turkish
• Published: Galenos Yayinevi Tic. Ltd 01.09.2019
• Subjects: Cold weather; Dermatitis; Development and progression; Diagnosis; Ferritin; Folic acid; Health aspects; Inflammation; Measurement; Risk factors; Skin; Vitamin B12; Turkey
• ISSN: 1019-214X; 2651-5164
• DOI: 10.4274/turkderm.galenos.2018.27576

Background and Design: Pernio is an inflammatory disease that occurs in the acral regions of the body after exposure to cold. The study aimed to investigate the demographic findings of patients diagnosed with pernio and to determine the role of vitamin B12, folate and ferritin values in the pathogenesis of pernio. Materials and Methods: This study was conducted in pernio patients diagnosed at the Agri State Hospital, Dermatology Outpatient Clinic (Agri, Turkey) between September 2015 and April 2016. The healthy control group participants were of similar age and gender. Vitamin B12, folate and ferritin levels were compared between the groups. Results: The patient and control groups were similar in age and gender. Vitamin B12 and ferritin levels were significantly lower in the patient group (p<0.05). Folate levels did not differ significantly between the groups (p>0.05). Conclusion: According to the data obtained from our study, when the demographic findings of the pernio patients were compared with those in the literature, the results were found to be similar. In the patients with pernio, it is likely that low Vitamin B12 was involved in the pernio etiology via the mechanism of vasoconstriction/vasodilatation. Keywords: Pernio, folic acid, vitamin B12, ferritin, demographic Amac: Pernio, soguga maruz kalma sonrasinda vucudun akral bolgelerinde olusan enflamatuvar bir hastaliktir. Calismamizda pernio hastalarinin demografik bulgulari incelenerek B12 vitamin, folat, ferritin duzeylerinin pernio patogenezindeki yerini bulmayi amacladik. Gerec ve Yontem: Bu calisma, Eylul 2015-Nisan 2016 tarihleri arasinda Agri Devlet Hastanesi Dermatololoji Poliklinigi'ne basvuran pernio tanisi alan hastalar ile benzer yas ve cinsiyet ozelliklerine sahip kontrol grubunda gerceklestirildi. Gruplarin B12 vitamin, folat, ferritin duzeyleri karsilastirildi. Bulgular: Hasta ve kontrol gruplari yas ve cinsiyet acisindan benzerdi. Hasta grubunda B12 vitamin ve ferritin duzeyi anlamli olarak dusuktu (p<0,05). Folat duzeyi acisindan olgu-kontrol gruplari arasinda fark bulunmadi (p>0,05). Sonuc: Calismamizda elde ettigimiz veriler isiginda pernio hastalarin demografik bulgulari literaturdeki calismalarla karsilastirildiginda, benzer sonuclar bulunmustur. Calismamizda B12 vitamin dusuklugunun homosistein mekanizmasi uzerinden vazospazma yol acmak suretiyle pernio patogenezinde rol almasi muhtemel olabilecegi dusunulmektedir. Anahtar Kelimeler: Pernio, folik asit, vitamin B12, ferritin, demografi