Is there any relationship between gene expression of tumor antigens and CD4.sup.+ T cells in multiple myeloma?

Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials & methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM)...

Full description

Saved in:
Bibliographic Details
Published inImmunotherapy Vol. 6; no. 5; p. 569
Main Authors Braga, Walter MT, da Silva, Bruna R, Alves, Veruska LF, Bortoluzo, Adriana B, Atanackovic, Djordje, Colleoni, Gisele WB
Format Journal Article
LanguageEnglish
Published Future Medicine Ltd 01.05.2014
Subjects
Gene expression
Genetic aspects
Health aspects
Multiple myeloma
Physiological aspects
T cells
Tumor antigens
Online AccessGet full text

Cover

More Information
Summary:Aim: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells. Materials & methods: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR. Results: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4.sup.+ T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow. Conclusion: Although CTAs and immunomodulatory CD4.sup.+ T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM.
ISSN:1750-743X
DOI:10.2217/imt.14.24