IMindReader/I: Unsupervised Classification of Electroencephalographic Data

• Published in: Sensors (Basel, Switzerland) Vol. 23; no. 6
• Main Authors: Rivas-Carrillo, Salvador Daniel, Akkuratov, Evgeny E, Valdez Ruvalcaba, Hector, Vargas-Sanchez, Angel, Komorowski, Jan, San-Juan, Daniel, Grabherr, Manfred G
• Format: Journal Article
• Language: English
• Published: MDPI AG 01.03.2023
• Subjects: Analysis; Care and treatment; Electroencephalography; Epilepsy; Evaluation; Machine learning; Markov processes; Medical research; Medicine, Experimental; Neural networks; Patients
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s23062971

Electroencephalogram (EEG) interpretation plays a critical role in the clinical assessment of neurological conditions, most notably epilepsy. However, EEG recordings are typically analyzed manually by highly specialized and heavily trained personnel. Moreover, the low rate of capturing abnormal events during the procedure makes interpretation time-consuming, resource-hungry, and overall an expensive process. Automatic detection offers the potential to improve the quality of patient care by shortening the time to diagnosis, managing big data and optimizing the allocation of human resources towards precision medicine. Here, we present MindReader, a novel unsupervised machine-learning method comprised of the interplay between an autoencoder network, a hidden Markov model (HMM), and a generative component: after dividing the signal into overlapping frames and performing a fast Fourier transform, MindReader trains an autoencoder neural network for dimensionality reduction and compact representation of different frequency patterns for each frame. Next, we processed the temporal patterns using a HMM, while a third and generative component hypothesized and characterized the different phases that were then fed back to the HMM. MindReader then automatically generates labels that the physician can interpret as pathological and non-pathological phases, thus effectively reducing the search space for trained personnel. We evaluated MindReader's predictive performance on 686 recordings, encompassing more than 980 h from the publicly available Physionet database. Compared to manual annotations, MindReader identified 197 of 198 epileptic events (99.45%), and is, as such, a highly sensitive method, which is a prerequisite for clinical use.