Association Between Interleukin 1 Beta Gen Varyasyonu ile Hippokampal Sklerozlu Temporal Lob Epilepsisi Iliskisi

• Published in: Türk nöroloji dergisi Vol. 27; no. 4; p. 390
• Main Authors: Sariteke, Alp, Uludag, Irem Fatma, Özyilmaz, Berk, Zorlu, Yasar, Sener, Ufuk, Tokuçoglu, Figen
• Format: Journal Article
• Language: English
• Published: Galenos Yayinevi Tic. Ltd 01.12.2021
• Subjects: Genetic aspects; Health aspects; Hippocampus (Brain); Interleukin-1; Neurological research; Risk factors; Sclerosis; Single nucleotide polymorphisms; Temporal lobe epilepsy; Turkey
• ISSN: 1301-062X; 1309-2545
• DOI: 10.4274/tnd.2021.70962

Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers. Results: The frequency of the -511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group. Conclusion: There was no association between the -511/C>T SNP variation and TLE+HS. Keywords: IL-1beta, temporal lobe epilepsy, hippocampal sclerosis, epilepsy, genetics Amaç: IL-1beta geni promotor bölgesinde artmis gen transkripsiyonu ile sonuçlanan bir polimorfizm ve hippokampal sklerozlu temporal lob epilepsisi klinik fenotipi (TLE+HS) arasindaki bir iliski olup olmadiginin arastirilmasi amaçlanmistir. Gereç ve Yöntem: Yirmi bir TLE+HS, 21 hippokampal skleroz olmayan temporal lob epilepsisi (TLE-HS) ve 23 saglikli gönüllüde IL-1beta geni 511. baz çiftinde C>T geçisine neden olan tek nükleotid polimorfizminin (SNP) sikligi arastirilmistir. Bulgular: -511T alleli sikligi TLE-HS'de 11/21, TLE+HS'de 13/21 ve normal kontrol grubunda 12/23 olarak bulunmustur. Genotip ve allel dagiliminin analizi TLE+HS, TLE-HS ve kontrol gruplari arasinda -511T alleli sikligi açisindan fark olmadigini göstermistir. Sonuç: Bu çalismanin sonuçlari -511/C>T SNP varyasyonu ile TLE+HS arasinda bir iliski varligini göstermemektedir. Anahtar Kelimeler: IL-1beta, temporal lob epilepsisi, hippokampal skleroz, epilepsi, genetik