Antihyperglycemic effect and antioxidant property of Citrus maxima leaf in streptozotocin-induced diabetic rats

The aim of the present study was to evaluate antihyperglycemic activity of methanol extract of Citrus maxima leaf (MECM) in streptozotocin (STZ; 65 mg/kg b.w.) induced diabetic rats. Three days after STZ induction, diabetic rats received MECM orally at a dose of 200 and 400 mg [kg.sup.-1] body weigh...

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Published inDiabetologia Croatica Vol. 40; no. 4; p. 113
Main Authors KunduSen, Sriparna, Gupta, Malaya, Mazumder, Upal K, Haldar, Pallab K, Saha, Prerona, Bhattacharya, Sanjib, Kar, Biswakanth, Bala, Asis
Format Journal Article
LanguageEnglish
Published Vuk Vrhovac Institute 01.12.2011
Subjects
Animal experimentation
Care and treatment
Chemical properties
Diabetes
Health aspects
Rutaceae
India
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Summary:The aim of the present study was to evaluate antihyperglycemic activity of methanol extract of Citrus maxima leaf (MECM) in streptozotocin (STZ; 65 mg/kg b.w.) induced diabetic rats. Three days after STZ induction, diabetic rats received MECM orally at a dose of 200 and 400 mg [kg.sup.-1] body weight daily for 15 days. Glibenclamide (0.5 mg [kg.sup.-1] p.o.) was used as a reference drug. Blood glucose levels were measured on days 0, 4, 8 and 15. Serum biochemical parameters viz. SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of the pancreas, kidney and liver were determined. MECM significantly (P<0.001) and in a dose dependent manner normalized blood glucose levels, serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present study inferred that in STZ-induced diabetic Wistar rats, C. maxima leaf demonstrated a potential antihyperglycemic effect that might be attributed to its antioxidant property. Key words: antihyperglycemic, Citrus maxima, streptozotocin, antioxidant, lipid peroxidation
ISSN:0351-0042