Comparative Study of Polycomplexes Based on Carbopol.sup.® and Oppositely Charged Polyelectrolytes as a New Oral Drug Delivery System

We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol.sup.® p...

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Bibliographic Details
Published inPharmaceutical chemistry journal Vol. 49; no. 1; p. 1
Main Authors Mustafin, R. I, Semina, I. I, Garipova, V. R, Bukhovets, A. V, Sitenkov, A. Yu, Salakhova, A. R, Gennari, C. G. M, Cilurzo, F
Format Journal Article
LanguageEnglish
Published Springer 01.04.2015
Subjects
Comparative analysis
Diclofenac
Drug delivery systems
Drugs
Glycoproteins
Polyelectrolytes
Polysaccharides
Vehicles
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Summary:We report here a comparative study of the release of model drug diclofenac sodium from samples of interpolyelectrolyte complexes (IPEC) in in vitro conditions on a rotating basket apparatus and in vivo in experiments in rabbits. The study IPEC were prepared using different grades of Carbopol.sup.® polymer (C71g, C2020) and Noveon.sup.® AA-1 and oppositely charged polyelectrolytes - Eudragit.sup.® EPO or the natural polysaccharide low-viscosity chitosan. These studies demonstrated the potential for IPEC samples based on Carbopol.sup.® as a new modified-release drug delivery system. At the same time, assessment of bioadhesive properties provided evidence of the potential for using IPEC based on C2020/EPO as a mucoadhesive carrier.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-015-1211-2