Heat-Killed IStaphylococcus aureus/I Induces Bone Mass Loss through Telomere Erosion

The mechanism of systemic osteoporosis caused by chronic infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore th...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 24; no. 4
Main Authors Deng, Songyun, Yang, Mankai, Su, Jianwen, Cui, Naiqian, Wu, Siyuan, Zhang, Guangyan, Wang, Lei, Hou, Yilong, Chai, Yu, Yu, Bin
Format Journal Article
LanguageEnglish
Published MDPI AG 01.02.2023
Subjects
Bones
Density
Health aspects
Inflammation
Medical research
Medicine, Experimental
Osteoporosis
Staphylococcus aureus
Telomerase
Telomeres
China
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Summary:The mechanism of systemic osteoporosis caused by chronic infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore the mechanism of systemic bone loss caused by it. In this study, we found that the systemic application of HKSA caused bone loss in mice. Further exploration found that HKSA caused cellular senescence, telomere length shortening, and telomere dysfunction-induced foci (TIF) in limb bones. As a well-known telomerase activator, cycloastragenol (CAG) significantly alleviated HKSA-induced telomere erosion and bone loss. These results suggested that telomere erosion in bone marrow cells is a possible mechanism of HKSA-induced bone loss. CAG may protect against HKSA-induced bone loss by alleviating telomere erosion in bone marrow cells.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24043179