Rapid spread of influenza A

A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 in...

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Published inInfluenza and other respiratory viruses Vol. 10; no. 4; p. 247
Main Authors Komissarov, Andrey, Fadeev, Artem, Sergeeva, Maria, Petrov, Sergey, Sintsova, Kseniya, Egorova, Anna, Pisareva, Maria, Buzitskaya, Zhanna, Musaeva, Tamila, Danilenko, Daria, Konovalova, Nadezhda, Petrova, Polina, Stolyarov, Kirill, Smorodintseva, Elizaveta, Burtseva, Elena, Krasnoslobodtsev, Kirill, Kirillova, Elena, Karpova, Lyudmila, Eropkin, Mikhail, Sominina, Anna, Grudinin, Mikhail
Format Journal Article
LanguageEnglish
Published John Wiley & Sons, Inc 19.03.2016
Subjects
Analysis
Epidemics
Genes
Genetic aspects
Genomes
Genomics
Health aspects
Influenza
Vaccines
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Summary:A dramatic increase of influenza activity in Russia since week 3 of 2016 significantly differs from previous seasons in terms of the incidence of influenza and acute respiratory infection (ARI) and in number of lethal cases. We performed antigenic analysis of 108 and whole-genome sequencing of 77 influenza A(H1N1)pdm09 viruses from Moscow and Saint Petersburg. Most of the viruses were antigenically related to the vaccine strain. Whole-genome analysis revealed a composition of specific mutations in the internal genes (D2E and M83I in NEP, E125D in NS1, M105T in NP, Q208K in M1, and N204S in PA-X) that probably emerged before the beginning of 2015/2016 epidemic season.
ISSN:1750-2640
1750-2659
DOI:10.1111/irv.12389