hydroxybutyrate and ischemic stroke: roles and mechanisms

Stroke is a significant global burden, causing extensive morbidity and mortality. In metabolic states where glucose is limited, ketone bodies, predominantly [beta]-hydroxybutyrate (BHB), act as alternative fuel sources. Elevated levels of BHB have been found in the ischemic hemispheres of animal mod...

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Bibliographic Details
Published inMolecular brain Vol. 17; no. 1
Main Authors Feng, Ge, Wu, Zongkai, Yang, Leyi, Wang, Kaimeng, Wang, Hebo
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 29.07.2024
Subjects
Amino acids
Analysis
Dextrose
Glucose
Glucose metabolism
Ischemia
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Summary:Stroke is a significant global burden, causing extensive morbidity and mortality. In metabolic states where glucose is limited, ketone bodies, predominantly [beta]-hydroxybutyrate (BHB), act as alternative fuel sources. Elevated levels of BHB have been found in the ischemic hemispheres of animal models of stroke, supporting its role in the pathophysiology of cerebral ischemia. Clinically, higher serum and urinary BHB concentrations have been associated with adverse outcomes in ischemic stroke, highlighting its potential utility as a prognostic biomarker. In both animal and cellular models, exogenous BHB administration has exhibited neuroprotective effects, reduction of infarct size, and improvement of neurological outcomes. In this review, we focus on the role of BHB before and after ischemic stroke, with an emphasis on the therapeutic potential and mechanisms of ketone administration after ischemic stroke. Keywords: [beta]-hydroxybutyrate, Ischemic stroke, Prognostic biomarker, Neuroprotective effect
ISSN:1756-6606
1756-6606
DOI:10.1186/s13041-024-01119-0