Interferon-[gamma], a valuable surrogate marker of Plasmodium falciparum pre-erythrocytic stages protective immunity

Immunity against the pre-erythrocytic stages of malaria is the most promising, as it is strong and fully sterilizing. Yet, the underlying immune effectors against the human Plasmodium falciparum pre-erythrocytic stages remain surprisingly poorly known and have been little explored, which in turn pre...

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Published inMalaria journal Vol. 10; p. 27
Main Authors Perlaza, Blanca-Liliana, Sauzet, Jean-Pierre, Brahimi, Karima, BenMohamed, Lbachir, Druilhe, Pierre
Format Journal Article
LanguageEnglish
Published BioMed Central Ltd 08.02.2011
Subjects
Health aspects
Immunity
Interferon gamma
Physiological aspects
Plasmodium falciparum
France
United States
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Summary:Immunity against the pre-erythrocytic stages of malaria is the most promising, as it is strong and fully sterilizing. Yet, the underlying immune effectors against the human Plasmodium falciparum pre-erythrocytic stages remain surprisingly poorly known and have been little explored, which in turn prevents any rational vaccine progress. Evidence that has been gathered in vitro and in vivo, in higher primates and in humans, is reviewed here, emphasizing the significant role of IFN-[gamma], either as a critical immune mediator or at least as a valuable surrogate marker of protection. One may hope that these results will trigger investigations in volunteers immunized either by optimally irradiated or over-irradiated sporozoites, to quickly delineate better surrogates of protection, which are essential for the development of a successful malaria vaccine.
ISSN:1475-2875
1475-2875
DOI:10.1186/1475-2875-10-27