High Expression of IncRNA HEIH is Helpful in the Diagnosis of Non-Small Cell Lung Cancer and Predicts Poor Prognosis

• Published in: Cancer management and research Vol. 14; p. 503
• Main Authors: He, Chaowen, Huang, Dongxuan, Yang, Fan, Huang, Dongsheng, Cao, Yahui, Peng, Jianfeng, Luo, Xiaohua
• Format: Journal Article
• Language: English
• Published: Dove Medical Press Limited 28.02.2022
• Subjects: Analysis; Cancer; CEA (Oncology); Lung cancer, Non-small cell; Lung cancer, Small cell; Metastasis; Oncology, Experimental; Prognosis; Risk factors; RNA; Squamous cell carcinoma; China; Taiwan
• ISSN: 1179-1322; 1179-1322
• DOI: 10.2147/CMAR.S320965

Background: This study aims to investigate the expression and clinical value of long non-coding RNA (IncRNA) HEIH in peripheral blood of patients with non-small cell lung cancer (NSCLC). Methods: Healthy subjects (N=70), patients with lung squamous cell carcinoma (LUSC, N=70) and patients with lung adenocarcinoma (LUAD, N=80) were included. LncRNA HEIH expression in peripheral blood of included subjects was detected using RT-qPCR. According to the median expression of IncRNA HEIH, LUSC and LUAD patients were allocated into IncRNA HEIH high/low expression groups. The correlation between IncRNA HEIH and clinical indicators of patients was analyzed; Logistic multifactor regression was used to analyze the independent risk factors influencing IncRNA HEIH level. Receiver-operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of IncRNA HEIH and carcinoembryonic antigen (CEA) in LUSC/LUAD patients. MedCalc-Comparison of ROC curves was used to compare the area under ROC curve. The cumulative survival rates of IncRNA HEIH high/low expression group were analyzed by Kaplan--Meier curve. COX multivariate analysis was used to assess the independent factors affecting prognosis of NSCLC. Results: LncRNA HEIH in peripheral blood of LUSC/LUAD patients was higher than that in healthy controls, with no evident difference between LUSC and LUAD groups. In LUSC/LUAD patients, TNM stage, lymph node metastasis, distal metastasis, and CEA were independent risk factors affecting IncRNA HEIH; patients with high IncRNA HEIH expression had larger pack-years and tumor size, higher CEA level and tumor stage, and higher risk of lymph node metastasis and distal metastasis. LncRNA HEIH had higher diagnostic efficiency than CEA in NSCLC patients. High expression of IncRNA HEIH predicted poor prognosis in patients with NSCLC and was an independent risk factor for prognosis of NSCLC. Conclusion: High expression of IncRNA HEIH is helpful in the diagnosis of NSCLC and predicts poor prognosis. Keywords: non-small cell lung cancer, long non-coding RNA HEIH, prognosis, carcinoembryonic antigen, lung squamous cell carcinoma, lung adenocarcinoma, peripheral blood